IASM 82 83: Medical Big Data and Adverse Drug Responses

Question 1

Clinical Data training

The training data needs to reflect ________

Answer 1

Reflect the characteristics of the target population

Question 2

Why will the use of medical big data breach the autonomy?

Answer 2

Hard to control the flow and access of data

Since we need to agree to share the data in order to use the mobile app

Question 3

Why will the use of medical big data cause loss of anonymity?

Answer 3

Data includes activity and location tracking, allowing identification of person’s address and identity even without his or her consent

Question 4

Why will the use of medical big data cause use of data beyond the intended purpose

Answer 4

Companies may use your data and deduce your general habit and preference, which may be used for unintended commercial purposes such as targeted marketing

Question 5

What are the types of Adverse Drug Reaction

ABCDEF

Answer 5

ABCDEF
Augmented
Bizarre
Chronic
Delayed
End-of-treatment
Failure of efficacy

Question 6

Adverse Drug Reaction (Augmented)
Name 3 Characteristics
- Is it pharmacological?
- Is it dose-dependent?
- Incidence and mortality?

• Name 1 drug with associated to this type

Answer 6

• Pharmacological
• Dose-dependent, will develop in most patients given a large dose
• High incidence but low mortality
• Example: Warfarin

Question 7

Adverse Drug Reaction (Bizarre)
Name 3 Characteristics
- Is it pharmacological?
- Is it dose-dependent?
- Incidence and mortality?

• Name 1 example

Answer 7

• Non-pharmacological (Often allergic)
• Unrelated to dose
• Low incidence but high mortality
• Example: SJS/TEN
• Example: ATD-induced agranulocytosis