IASM 48: Process in Healing of Health and Disease Flashcards
What are the 4 stages of tissue response to injury 1. 2. 3. 4.
Acute inflammation
Demolition
Healing, Repair
Resolution
What is meant by repair?
Replacement of lost tissue by __________ tissue
Granulation tissue matures to form scar (_____ tissue)
Replacement of lost tissue by granulation tissue
Granulation tissue matures to form scar (fibrous tissue)
In repair, there is replacement of lost tissue by granulation tissue. Name 3 components of granulation tissues?
Proliferating capillaries to deliver more oxygen and nutrients
Fibroblasts and myofibroblasts
Macrophages
What is meant by regeneration?
Lost tissue is replaced by ___________
Lost tissue is replaced by a similar type of tissue
By regenerative capacity of cells, we can divide the cells into 3 types.
- __________- Continuous division, cells in the cell cycle
- __________- Cells came out from cell cycle, but able to go back into the cycle
- __________- Cells exited the cell cycle already, non-proliferative
- Labile cells- Continuous division, cells in the cell cycle
- Stable cells- Cells came out from cell cycle, but able to go back into the cycle
- Permanent cells- Cells exited the cell cycle already, non-proliferative
By regenerative capacity of cells, we can divide the cells into 3 types.
Are they able to divide? Are they in the cell cycle?
1. Labile cells-
2. Stable cells-
3. Permanent cells-
- Labile cells- Continuous division, cells in the cell cycle
- Stable cells- Cells came out from cell cycle, but able to go back into the cycle
- Permanent cells- Cells exited the cell cycle already, non-proliferative
By regenerative capacity of cells, we can divide the cells into 3 types. Provide examples of each type? 1. Labile cells- 2. Stable cells- 3. Permanent cells-
- Labile cells- RBCs, Skin, lining of organs
- Stable cells- Liver cells
- Permanent cells- Neurones, Cardiac Muscle Cells
In regeneration, there will be proliferation of the surrounding ____________ cells. However, the cells will need to stop proliferating after the effect of the injury has been healed, because when they keep multiplying, it will result in a _______.
In regeneration, there will be proliferation of the surrounding undamaged specialized cells. However, the cells will need to stop proliferating after the effect of the injury has been healed, because when they keep multiplying, it will result in a tumour.
Scar formation
_______ will secrete extracellular matrix components. This includes type ___ collagen.
Eventually type ___ collagen will be replaced by type ___ collagen for permanent scar formation.
Scar formation
Fibroblasts will secrete extracellular matrix components. This includes type 3 collagen.
Eventually type 3 collagen will be replaced by type 1 collagen for permanent scar formation.
Healing of skin wounds- Scar Formation
- Acute ______ results in formation of a _______
- There is epithelial _________ and formation of ________ tissue
- Capillaries reformed and ___________ are deposited
- Formation of a scar
Healing of skin wounds
- Acute inflammation results in formation of a scab
- There is epithelial regeneration and formation of granulation tissue
- Capillaries reformed and collagen fibres are deposited
- Formation of a scar
Healing of bone fractures
- __________ engulf the debris and dead cells
- ________ formation to bridge the gap
- Activity of two types of cells : _______ (building) and ________ (Destroying)
- Formation of __________ bone to replace the callus
- Fracture site becomes invisible
Healing of bone fractures
- Phagocytes engulf the debris and dead cells
- Callus formation to bridge the gap
- Activity of two types of cells : Osteoblasts (building) and Osteoclasts (Destroying)
- Formation of lamellar bone to replace the callus
- Fracture site becomes invisible
What is the difference between healing by primary intention and healing by secondary intention? Compare the following:
- Amount of Granulation tissue
- Amount of Necrotic tissue
- Size of scar
- Speed of process
Primary Intention VS Secondary Intention
- Less VS More
- Less VS More
- Small VS Large
- Faster VS Slower
Name 2 reasons that will slow down the healing process in human bodies
- Poor nutrition (e.g. lack of protein and Vitamin C)
2. Steroid Administration (Steroids are anti-inflammatory)
Name 1 reason that will enhance the healing effect
UV light will accelerate healing in human bodies
Complications of wound healing:
When wound has broken, it is called ______
When excessive scar tissue is formed, it is called ____
When nerve endings are not put together, it will cause _____
Pigmentation is caused by breakdown of _______ with excessive bleeding
Narrowing, Stenosis of lumen is called ________
Complications of wound healing:
When wound has broken, it is called dehiscence
When excessive scar tissue is formed, it is called Keloid
When nerve endings are not put together, it will cause neuroma
Pigmentation is caused by breakdown of haemosiderin with excessive bleeding
Narrowing, Stenosis of lumen is called Cicatrization
