IASM 28: Connective Tissues (NEW) Flashcards
Where is the origin of connective tissues
Mesoderm from embryo
Name the 4 components in connective tissue proper
Lamina propria
Dermis of skin
Tendon
Ligaments
In connective tissues, there’s the cellular component and the extracellular matrix.
Name 5 types of cells under ‘cellular components’
Fibroblasts Fat cells Macrophages Mast cells Plasma cells
In connective tissues, there’s the cellular component and the extracellular matrix.
Name 2 sub-components under ECM
Fibrous component
Ground Substance
In connective tissues, there’s the cellular component and the extracellular matrix.
Under ECM, there are two sub-components- Fibrous Component and the Ground Substance.
Name 2 sub-sub components under Ground Substance
Proteoglycan
Glycoproteins
In connective tissues, there’s the cellular component and the extracellular matrix.
Under ECM, there are two sub-components- Fibrous Component and the Ground Substance.
Under Ground Substance, there is Proteoglycans and Glycoproteins. What two components are proteoglycans made up of?
Core protein
GAG
Different proteoglycans join to a ‘horizontal chain’ of ________
Hyaluronic Acid
Name 3 functions of connective tissues
Support epithelial tissue
Protection
Tissue repair
Name 3 major types of fibers in connective tissues
Collagen Fiber
Reticular Fiber
Elastic Fiber
Which type of collagen fiber is the most abundant in human body
Type I
Tropocollagen is a Triple Helix
Name the 3 strands
Name the 3 amino acids making those strands
Alpha 1, Alpha 1, Alpha 2
Glycine, Proline, Hydroxyproline
Type I Collagen:
Which 2 cells produce them?
Where are they located in the body?
Fibroblasts, Osteoblasts
Dermis of skin, tendons, ligaments, bones
Type II Collagen:
Which cell produce them?
Where are they located in the body?
Chondroblasts
Hyaline Cartilage
Type III Collagen:
Which cell produce them?
Where are they located in the body?
Fibroblasts
Reticular Fibres
Type IV Collagen:
Which cell produce them?
Where are they located in the body?
Epithelial Cells
Basal lamina
Reticular Fibres:
- Which type of collagen?
- Visible under H&E Staining?
- Visible by silver stain?
- Is it PAS Positive?
Reticular Fibres:
- Which type of collagen? Type III
- Visible under H&E Staining? No
- Visible by silver stain? Yes
- Is it PAS Positive? Yes (Have glycoproteins)
Name a disease due to the mutation of elastic fibres
Marfan’s syndrome
Elastic Fibres:
- Visible under H&E Staining?
- It has an amorphous core of ______
Elastic Fibres:
- Visible under H&E Staining? No
- It has an amorphous core of elastin
Name an example of loose connective tissue
A component of Connective Tissue Proper
Lamina propria
Name an example of dense irregular connective tissue
A component of Connective Tissue Proper
Dermis of skin
Name an example of dense regular connective tissue
A component of Connective Tissue Proper
Tendon
Ligament
What is the most common cell type in connective tissue
A component of Connective Tissue Proper
Fibroblasts
What does the fibroblasts do?
Synthesize Fibrous Components and Ground Substance (under the ECM, non-cellular component)
Response to tissue damage and synthesize new matrix
Plasma cell has prominent ______
Golgi Apparatus
Describe the nucleus of plasma cell
2 features
Clock-face
Eccentrically located
