IASM 28: Connective Tissues (NEW)

Question 1

Where is the origin of connective tissues

Answer 1

Mesoderm from embryo

Question 2

Name the 4 components in connective tissue proper

Answer 2

Lamina propria
Dermis of skin
Tendon
Ligaments

Question 3

In connective tissues, there’s the cellular component and the extracellular matrix.

Name 5 types of cells under ‘cellular components’

Answer 3

Fibroblasts
Fat cells
Macrophages
Mast cells
Plasma cells

Question 4

In connective tissues, there’s the cellular component and the extracellular matrix.

Name 2 sub-components under ECM

Answer 4

Fibrous component

Ground Substance

Question 5

In connective tissues, there’s the cellular component and the extracellular matrix.

Under ECM, there are two sub-components- Fibrous Component and the Ground Substance.

Name 2 sub-sub components under Ground Substance

Answer 5

Proteoglycan

Glycoproteins

Question 6

In connective tissues, there’s the cellular component and the extracellular matrix.

Under ECM, there are two sub-components- Fibrous Component and the Ground Substance.

Under Ground Substance, there is Proteoglycans and Glycoproteins. What two components are proteoglycans made up of?

Answer 6

Core protein

GAG

Question 7

Different proteoglycans join to a ‘horizontal chain’ of ________

Answer 7

Hyaluronic Acid

Question 8

Name 3 functions of connective tissues

Answer 8

Support epithelial tissue
Protection
Tissue repair

Question 9

Name 3 major types of fibers in connective tissues

Answer 9

Collagen Fiber
Reticular Fiber
Elastic Fiber

Question 10

Which type of collagen fiber is the most abundant in human body

Answer 10

Type I

Question 11

Tropocollagen is a Triple Helix
Name the 3 strands
Name the 3 amino acids making those strands

Answer 11

Alpha 1, Alpha 1, Alpha 2

Glycine, Proline, Hydroxyproline

Question 12

Type I Collagen:
Which 2 cells produce them?
Where are they located in the body?

Answer 12

Fibroblasts, Osteoblasts

Dermis of skin, tendons, ligaments, bones

Question 13

Type II Collagen:
Which cell produce them?
Where are they located in the body?

Answer 13

Chondroblasts

Hyaline Cartilage

Question 14

Type III Collagen:
Which cell produce them?
Where are they located in the body?

Answer 14

Fibroblasts

Reticular Fibres

Question 15

Type IV Collagen:
Which cell produce them?
Where are they located in the body?

Answer 15

Epithelial Cells

Basal lamina

Question 16

Reticular Fibres:

• Which type of collagen?
• Visible under H&E Staining?
• Visible by silver stain?
• Is it PAS Positive?

Answer 16

Reticular Fibres:

• Which type of collagen? Type III
• Visible under H&E Staining? No
• Visible by silver stain? Yes
• Is it PAS Positive? Yes (Have glycoproteins)

Question 17

Name a disease due to the mutation of elastic fibres

Answer 17

Marfan’s syndrome

Question 18

Elastic Fibres:

• Visible under H&E Staining?
• It has an amorphous core of ______

Answer 18

Elastic Fibres:

• Visible under H&E Staining? No
• It has an amorphous core of elastin

Question 19

Name an example of loose connective tissue

A component of Connective Tissue Proper

Answer 19

Lamina propria

Question 20

Name an example of dense irregular connective tissue

A component of Connective Tissue Proper

Answer 20

Dermis of skin

Question 21

Name an example of dense regular connective tissue

A component of Connective Tissue Proper

Answer 21

Tendon

Ligament

Question 22

What is the most common cell type in connective tissue

A component of Connective Tissue Proper

Answer 22

Fibroblasts

Question 23

What does the fibroblasts do?

Answer 23

Synthesize Fibrous Components and Ground Substance (under the ECM, non-cellular component)
Response to tissue damage and synthesize new matrix

Question 24

Plasma cell has prominent ______

Answer 24

Golgi Apparatus

Question 25

Describe the nucleus of plasma cell

2 features

Answer 25

Clock-face

Eccentrically located