neurotransmitters in the brain Flashcards
what are the 2 ways to record neuronal activity
1.cellular level
2.systems level
what 2 systems levels divided into ?
1.invasive
2.non-invasive
how do you correlate activity with behaviour ?
record activity while the behaviour occurring
2 ways you can record activity of behaviour?
1.electroencenphalogram (EEG)
2.advanced imaging techniques
EEG recording
activity patterns of populations of neurones.Patterns of synchrony causes rhythms
In EEG, what happens if neurones fire together ?
there are amplitude oscillations, slower frequency
-if there is less coordination , there will be low amplitude but higher frequency
how many plates are there in EEG
20-256 plate electrodes
in EEG where do you record voltage deflections?
relative to ‘ground’ electrode -usually the ear
what do you read when
recording the EEG?
electrode position mapped for ease of correlation with recording
what are the 5 the rhythms in the EEG
1.Alpha-8-13Hz
2.Beta -14Hz
3.Gamma-40Hz
4.Theta-4-7Hz
5.Delta-deep sleep, coma
Alpha function
mainly occipital, quiet, eyes shut
Beta function
Activity and tension
Gamma function
‘binding’ learning and memory
theta function
alertness, learning and memory
Delta function
Deep sleep, coma
what happens to the frequencies as you progress from waking to sleep?
faster to slower frequencies
what do the frequency patterns show in vegetative state ?
slow patterns , sleep-cycles present
what do the frequency patterns show in locked-in syndrome
normal
what do frequency patterns show in minimally conscious state
this is variable -mix of vs and coma
what do frequency patterns show in coma
slow, fixed patterns, no sleep-cycle present
what do frequency patterns show in brain death?
flatline
what is EEG useful to determine?
epilepsy
what does epileptiform show?
distinct patterns according to type
what can correlate with presence of auras and auditory hallucinations
onset of activity easy to pinpoint
focal seizures
small localised region of brain affected
focal to generalised
small local region spreading to whole/half brain
generalised
whole hemisphere/brain affected
what are 2 popular tools for researchers
1.sleep studies
2.behavioural/psychological studies
what are 4 potential biomarkers for EEG
1.depression
2.cognitive decline
3.therapeutic potential
4.rehabilitation