Multiple Sclerosis Flashcards
MS: type of disease and target
- autoimmune disease
- target: CNS myelin
demyelinating lesions
- in gray AND white matter
- gray matter demyelination contributes to cognitive sx
- MRI does not show cortical demyelination
in MS, there is a shift to a ___-inflammatory state
in MS, there is a shift to a PRO-inflammatory state
-to treat, want to shift back to an anti-inflammatory state
cause of MS
- genetics
- infections (EBV)
- environmental exposure
- low vitamin D
age of onset of MS
20-40 years
-means they will have the disease for ~60 years
inflammation causes
- relapses
- new MRI lesions
neurodegenerative component of MS
- independent of relapses and new MRI lesions
- slow steady progression of disease
first sign of MS
-MRI lesion
______ is the most sensitive clinical tool for MS
MRI is the most sensitive clinical tool for MS
relapsing MS
- new attack every 1-2 years
- recover from attack
- cycle
radiologically isolated syndrome (RIS)
- have MRI lesions
- no clinical symptoms
- will likely have clinical sx in 5 years
_________ dominates in early phases of disease, _________ dominates in later phases
INFLAMMATION dominates in early phases of disease, NEURODEGENERATION dominates in later phases
treatment of MS is good at targeting ___________, but not _________
treatment of MS is good at targeting INFLAMMATION, but not NEURODEGENERATION
MS relapse
- acutely progressive neurological sx lasting 24 hours or more
- can be virtually any symptom
- early in disease, sx usually go away
symptoms of MS
- numbness, tingling
- walking difficulty
- vision problems
- weakness
- muscle spasms
