Microcytic Anemias Lecture Powerpoint Flashcards
Amber this time round
Hemoconcentration
Increase in proportion of RBC’s relative to the plasma
Hemodilution
Decrease in proportion of RBC’s relative to plasma
A problem with the alpha or B protein chains on the hemoglobin is what type of disorder?
Thalassemia
Porphyria definition
Presence of an altered heme porphyrin ring on the hemoglobin molecule resulting in microcytic hypochromic anemia, very very very rare condition
Sideroblastic anemia definition, how does it appear on a peripheral smear?
Occurs when bone marrow produces ringed sideroblasts opposed to proper RBC’s
Appears to have central pallor in it like a donut hole
The number 1 cause of hypochromatic, microcytic anemia
Iron deficiency anemia
Heme iron vs non heme iron absoprtion rate (animal vs plant product)
Heme iron is absorbed much better than non heme
Most common type of anemia in the world
Iron deficiency anemia
Most common cause of iron deficiency anemia in US
Not diet, but actually blood loss
Hematemesis definition
Vomitting of blood
Melena definition
Dark colored bloody stool indicative of upper GI bleed
Hematochezia definiton
Light colored bloody stool indicative of colon bleeding
Pica definition and examples indicative of iron deficiency
Eating items not considered food, ice, clay, and starch are examples
Plummer-Vinson syndrome triad of symptoms
- iron deficiency anemia
- dysphagia
- esophageal webs
Most common symptom seen in a patient suffering a PE
Tachycardia
Angular stomatitis is indicative of…
…iron deficiency anemia
Koilonychia definition and what is it indicative of?
abnormally thin spoon nails, indicative of iron deficiency anemia
All RBC indices will be ___ in microcytic hypochromatic anemia
Low
Serum ferritin test function
The most reliable gold standard test for evaluation of iron present in serum
Iron deficiency sees serum iron ___, total iron bindig capacity ___, and serum ferritin ____
- decrease
- increase
- decrease
Sideroblastic anemia is a __cytic, ___chromatic anemia with iron ____
micro, hypo, overload
Acquired sideroblastic anemia sources (4)
- alcohol
- lead
- B6 deficiency
- lupus
Sideroblastic anemia will have a ____chromatic peripheral smear with something called ____
hypo, basophilic stippling
Target cells on peripheral smears are indicative of…
….thalassemia
Sideroblasic anemia treatment
Chelation therapy
