medicine and science Flashcards
What is the scientific method
- observation/experiments
- explanation (hypothesis) which can be tested
- prediction
- experimentation and data interpretation
- confirmation (or not) of the hypothesis
- peer review
- publication (conference/academic journal)
What are some funding bodies towards research
pharmaceutical industry
government
charities
example of marketed antiviral drug
tamiflu
What can lead to ‘bad science’
under recruitment in trials no published protocols placebo capsules contained in dehyrocholic acid and dibasic calcium phosphate dehydrate unidentifiable authors missing statistical analyses
tell me about Pfizer
was said to treat a range of neurological disorders such as bi solar epilepsy migraines e.t.c
What a primary research study
direct experimentation:
-in vitro models (molecular biology, cell and tissue culture, isolated tissue and organs
-in vivo testing (animals and volunteers (artificial control over biological variables)
clinical trials:
drug treatments and follow up
surveys
secondary research study
- review (expert summery of a number of research studies)
- systematic review (objective analysis of all qualifying primary research studies
- meta-analysis-integrated analysis of the numerical data from all qualifying studies
evidence pyramid
randomised control trail is the peak as very reliable whereas an ‘expert opinion’ or meeting someone at the union may be biased
peer review
this is the process of subjecting an authors scholarly work or ideas to scrutiny of anonymous referees who are experts in the field
what does peer review ensure
authors meet the standards of their discipline and of science generally