First Aid Drug Toxicities & Interactions Flashcards by Caitlin Heim

Coronary vasospasm

C-TEAM Cocaine, Triptan, Ergot alkaloids, Amphetamine, Methamphetamine

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Cutaneous flushing

VANC: Vancomycin, Adenosine, Niacin, Ca2+ channel blockers (amlodipine specifically)

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Dilated cardiomyopathy

Doxorubicin (Adriamycin), daunorubicin

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Torsades de pointes

CAMP Class 13a RAT, Chloroquine, Antipsychotics (chlorpromazine, phenothiazide, ziprasidone) Macrolides Protease inhibitors Class 1a:disopyramide, quinidine, procainamide Class 3 (besides amiodirone):ibutilide, dofetilide, sotalol Ranalozine Antihistamines TCA’

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Agranulocytosis

Dapsone, Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole (Drugs CCCrush Myeloblasts and Promyelocytes)

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Aplastic anemia

Carbamazepine, Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

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Direct Coombs positive hemolytic anemia

Methyldopa, Penicillin

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Gray baby syndrome

Chloramphenicol

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Hemolysis in G6PD-deficient patients

Isoniazid (INH), Sulfonamides, Dapsone, Fava Beans, Napthalene, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin (hemolysis IS DFN PAIN)

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Megaloblastic anemia

Phenytoin, Methotrexate, Sulfa drugs (having a blast with PMS)

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Thrombocytopenia

Heparin, cimetidine(H2 blocker)

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Thrombosis

OCPs

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Cough

ACE inhibitors (note: ARBs like losartan - no cough)

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Pulmonary fibrosis

Bleomycin, Amiodarone, Busulfan, Methotrexate (Breathing Air Badly from Medications)

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Acute cholestatic hepatitis

Macrolides (Erythromycin)

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Focal to massive hepatic necrosis

Halothane, Amanita phalloides, Valproic acid, Acetaminophen (liver HAVAc)

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Hepatitis

INH

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Pseudomembranous colitis

Clindamycin, ampicillin, cephalosporins

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Adrenocortical insufficiency

Glucocorticoid withdrawal (HPA suppression)

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Gynecomastia

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole, Pot (Some Drugs Create Awesome Knockers)

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Hot flashes

Tamoxifen, clomiphene

Hypothyroidism

Lithium, amiodarone, sulfonamides (Fat SAL)

Hyperglycemia

Tacrolimus, protease inhibitors, Niacin, HCTZ, B blockers, Corticosteroids (Taking Pills Necessiates Having Blood Checked)

Fat redistribution

Glucocorticoids, protease inhibitors Fat PiG

Gingival hyperplasia

Phenytoin, verapamil, cyclosporine, nifedipine

Gout

Furosemide, thiazides, niacin, cyclosporine, pyrazinamide (Painful Tophi and Feet Need Care)

Myopathies

Fibrates, Niacin, Colchicine, Hydroxychlorquine, Interferon-α, Penicillamine, Statins, Glucocorticoids, (Fish N CHIPS Give you myopathies)

Osteoporosis

Corticosteroids, heparin

Photosensitivity

Sulfonamides, Amiodarone, Tetracycline, Quinolone (SAT for a photo)

Rash (Stevens Johnson syndrome)

Anti-epileptics (Ethosuximide, Carbamazepine, Lamotrigine, Phenytoin, Phenobarbital) Allopurinol, Sulfa Drugs, Penicillin

SLE-Iike syndrome

SHIPPE MAQ: Sulfa Drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept, Minocyline, a-methyldopa, quinidine

Teeth (kids)

Tetracyclines

Tendonitis, tendon rupture, and cartilage damage (kids)

Fluoroquinolones

Diabetes insipidus

Lithium, demeclocycline

Fanconi's syndrome

Expired tetracycline, Heavy metal exposure wilsons disease

Interstitial nephritis

Methicillin, NSAIDs, furosemide

Hemorrhagic cystitis

Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

SIADH

Carbamazepine, cyclophosphamide, SSRI's (Cant Concentrate Serum Sodium)

Cinchonism

Quinidine, quinine, salicylates

Parkinson-like syndrome

Antipsychotics, reserpine, metoclopramide (rigidity of ARM)

Seizures

Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide (With seizures I BITE My tongue) Alcohol/Benzo withdrawal

Tardive dyskinesia

Antipsychotics, metoclopramide

Antimuscarinic

Atropine, TCAs, H1 blockers, neuroleptics, digoxin

Disulfiram-like reaction

Metronidazole, certain cephalosporins (cefoperazone), griseofulvin, procarbazine, 1st-generation sulfonylureas,

Nephrotoxicity/ ototoxicity

CLAV: Aminoglycosides, vancomycin, loop diuretics, cisplatin,

P-450 inducers

CRABS MPNG, Carbamazepine Rifampin Alcohol use: Chronic Barbs St. Johns Wart Modafinil Phenytoin Nevirapine Griseofulvin

P-450 inhibitors

MAGIC RACKS GQV Macrolides Amiodarone Grapefruit juice INH Cimetidine Ritonavir (Protease -) Alcohol: Acute Ciproflaxacin (flouro) Ketoconazole (-azoles) Sulfonamides Gemfibrozil Quinidine Valproic acid

P 450 Substrates

Anti-epileptics Antidepressants Antipsychotics Anesthetics Theophylline Warfarin Statins OCPs Always Always Always Always Think When Starting Others

Sulfa drugs

Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas. (Popular FACTSSS) Patients with sulfa allergies may develop fever, urinary tract infection, pruritic rash, Stevens-Johnson syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives). Symptoms range from mild to life-threatening.

Nephrogenic DI

lithium Demeclocyline

Nephrotoxicity and neurotoxicity

Aminoglycosides, cisplatin, polymxin