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USMLE Step 1 > First Aid Drug Toxicities & Interactions > Flashcards

First Aid Drug Toxicities & Interactions Flashcards

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USMLE® Step 1 flashcards
1
Q

Coronary vasospasm

A

C-TEAM Cocaine, Triptan, Ergot alkaloids, Amphetamine, Methamphetamine

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2
Q

Cutaneous flushing

A

VANC: Vancomycin, Adenosine, Niacin, Ca2+ channel blockers (amlodipine specifically)

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3
Q

Dilated cardiomyopathy

A

Doxorubicin (Adriamycin), daunorubicin

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4
Q

Torsades de pointes

A

CAMP Class 13a RAT, Chloroquine, Antipsychotics (chlorpromazine, phenothiazide, ziprasidone) Macrolides Protease inhibitors Class 1a:disopyramide, quinidine, procainamide Class 3 (besides amiodirone):ibutilide, dofetilide, sotalol Ranalozine Antihistamines TCA’

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5
Q

Agranulocytosis

A

Dapsone, Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole (Drugs CCCrush Myeloblasts and Promyelocytes)

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6
Q

Aplastic anemia

A

Carbamazepine, Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

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7
Q

Direct Coombs positive hemolytic anemia

A

Methyldopa, Penicillin

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8
Q

Gray baby syndrome

A

Chloramphenicol

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9
Q

Hemolysis in G6PD-deficient patients

A

Isoniazid (INH), Sulfonamides, Dapsone, Fava Beans, Napthalene, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin (hemolysis IS DFN PAIN)

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10
Q

Megaloblastic anemia

A

Phenytoin, Methotrexate, Sulfa drugs (having a blast with PMS)

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11
Q

Thrombocytopenia

A

Heparin, cimetidine(H2 blocker)

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12
Q

Thrombosis

A

OCPs

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13
Q

Cough

A

ACE inhibitors (note: ARBs like losartan - no cough)

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14
Q

Pulmonary fibrosis

A

Bleomycin, Amiodarone, Busulfan, Methotrexate (Breathing Air Badly from Medications)

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15
Q

Acute cholestatic hepatitis

A

Macrolides (Erythromycin)

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16
Q

Focal to massive hepatic necrosis

A

Halothane, Amanita phalloides, Valproic acid, Acetaminophen (liver HAVAc)

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17
Q

Hepatitis

A

INH

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18
Q

Pseudomembranous colitis

A

Clindamycin, ampicillin, cephalosporins

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19
Q

Adrenocortical insufficiency

A

Glucocorticoid withdrawal (HPA suppression)

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20
Q

Gynecomastia

A

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole, Pot (Some Drugs Create Awesome Knockers)

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21
Q

Hot flashes

A

Tamoxifen, clomiphene

22
Q

Hypothyroidism

A

Lithium, amiodarone, sulfonamides (Fat SAL)

23
Q

Hyperglycemia

A

Tacrolimus, protease inhibitors, Niacin, HCTZ, B blockers, Corticosteroids (Taking Pills Necessiates Having Blood Checked)

24
Q

Fat redistribution

A

Glucocorticoids, protease inhibitors Fat PiG

25
Q

Gingival hyperplasia

A

Phenytoin, verapamil, cyclosporine, nifedipine

26
Q

Gout

A

Furosemide, thiazides, niacin, cyclosporine, pyrazinamide (Painful Tophi and Feet Need Care)

27
Q

Myopathies

A

Fibrates, Niacin, Colchicine, Hydroxychlorquine, Interferon-α, Penicillamine, Statins, Glucocorticoids, (Fish N CHIPS Give you myopathies)

28
Q

Osteoporosis

A

Corticosteroids, heparin

29
Q

Photosensitivity

A

Sulfonamides, Amiodarone, Tetracycline, Quinolone (SAT for a photo)

30
Q

Rash (Stevens Johnson syndrome)

A

Anti-epileptics (Ethosuximide, Carbamazepine, Lamotrigine, Phenytoin, Phenobarbital) Allopurinol, Sulfa Drugs, Penicillin

31
Q

SLE-Iike syndrome

A

SHIPPE MAQ: Sulfa Drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept, Minocyline, a-methyldopa, quinidine

32
Q

Teeth (kids)

A

Tetracyclines

33
Q

Tendonitis, tendon rupture, and cartilage damage (kids)

A

Fluoroquinolones

34
Q

Diabetes insipidus

A

Lithium, demeclocycline

35
Q

Fanconi’s syndrome

A

Expired tetracycline, Heavy metal exposure wilsons disease

36
Q

Interstitial nephritis

A

Methicillin, NSAIDs, furosemide

37
Q

Hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

38
Q

SIADH

A

Carbamazepine, cyclophosphamide, SSRI’s (Cant Concentrate Serum Sodium)

39
Q

Cinchonism

A

Quinidine, quinine, salicylates

40
Q

Parkinson-like syndrome

A

Antipsychotics, reserpine, metoclopramide (rigidity of ARM)

41
Q

Seizures

A

Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide (With seizures I BITE My tongue) Alcohol/Benzo withdrawal

42
Q

Tardive dyskinesia

A

Antipsychotics, metoclopramide

43
Q

Antimuscarinic

A

Atropine, TCAs, H1 blockers, neuroleptics, digoxin

44
Q

Disulfiram-like reaction

A

Metronidazole, certain cephalosporins (cefoperazone), griseofulvin, procarbazine, 1st-generation sulfonylureas,

45
Q

Nephrotoxicity/ ototoxicity

A

CLAV: Aminoglycosides, vancomycin, loop diuretics, cisplatin,

46
Q

P-450 inducers

A

CRABS MPNG, Carbamazepine Rifampin Alcohol use: Chronic Barbs St. Johns Wart Modafinil Phenytoin Nevirapine Griseofulvin

47
Q

P-450 inhibitors

A

MAGIC RACKS GQV Macrolides Amiodarone Grapefruit juice INH Cimetidine Ritonavir (Protease -) Alcohol: Acute Ciproflaxacin (flouro) Ketoconazole (-azoles) Sulfonamides Gemfibrozil Quinidine Valproic acid

48
Q

P 450 Substrates

A

Anti-epileptics Antidepressants Antipsychotics Anesthetics Theophylline Warfarin Statins OCPs Always Always Always Always Think When Starting Others

49
Q

Sulfa drugs

A

Probenecid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfonamide antibiotics, Sulfasalazine, Sulfonylureas. (Popular FACTSSS) Patients with sulfa allergies may develop fever, urinary tract infection, pruritic rash, Stevens-Johnson syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives). Symptoms range from mild to life-threatening.

50
Q

Nephrogenic DI

A

lithium Demeclocyline

51
Q

Nephrotoxicity and neurotoxicity

A

Aminoglycosides, cisplatin, polymxin

USMLE Step 1 (97 decks)

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