Antibiotics: MOA

Question 1

Fluoroquinolones: MOA

Answer 1

• bactericidal
• inhibit DNA topoisomerase activity

Question 2

Fluoroquinolones: adverse effects

Answer 2

• GI upset
• damage to cartilage @ children
• tendinitis/tendon rupture in adults
• mild
  
  • H/A
  • dizziness
  • rash

Question 3

Aminoglycosides: MOA

Answer 3

• bactericidal
• block bacterial protein synthesis through inhibition of 30S ribosomal unit

Question 4

Aminoglycosides: adverse effects

Answer 4

• nephrotoxicity
• ototoxicity

Question 5

Macrolides: MOA

Answer 5

• bacteriostatic
• blocks protein syntehesis at 50S ribosomal unti

Question 6

Macrolides: adverse effects

Answer 6

• GI discomfort
• acute cholestatic hepatitis
• eosinophilia
• skin rashes
• more severe
  
  • pseudomembranous colitis
  • ventricular arrhythmias

Question 7

Tetracyclines: MOA

Answer 7

• bacteriostatic agents
• block protein synthesis by actin at 30S ribosomal subunit

Question 8

Tetracyclines: adverse effects

Answer 8

• GI distress
• tooth discoloration
• inhibition of bone growth @ children
• photosensitivity rxns
• more severe
  
  • bacterial superinfection
  • hepatotoxicity

Question 9

Trimethoprim-sulfamethoxazole: MOA

Answer 9

• trimethoprim-sulfamethoxazole
  
  • MOA = inhibitis bacterial folate synthesis via inhibition:
  • dihydropteroate synthetase (trimetho) and dihydrofolate reductase (sulfa)

Question 10

Penicillins: MOA

Answer 10

• bactericidal
• inhibition of cell wall synthesis via inhibition of cross-linking of peptidoglycan