Diagnosis of AI disease Flashcards
what are the four factors associated with an autoimmune disease test
sensitivity (true positive)
specificity (true negative)
positive predictive value - proportion of positive tests with disorder
negative predictive value - proportion of negatives without disorder
what are the two types of diagnostic tests
non-specific - inflammatory markers doesn’t tell you what is happening
disease specific - autoantibody testing
HLA typing - what autoimmune diseases are susceptible
what are some examples of inflammatory markers
ESR, CRP, ferritin, fibrinogen, hepatoglobin, albumin, complement
describe the process of ANA testing for specific autoimmune disease
antinuclear antibodies
uses microbes-based immunoassay to match antibody agains specific known antibodies with fluorescent marker
what is crithida luciliae assay detect
protozoa with anti-dsDNA
what is the autoantibody of SLE
dsDNA auto-antibody
what does rheumatoid factor detect for
Fc portion of IgG attacking IgG of patient - not that specific or sensitive only about 70%
what does antiCCP antibody test for - ACPA
specific for RA better than RF for specificity
what does anti-neutrophilic cytoplasmic antibodies (ANCA) test for
for possible vasculitis or granulomatosis with polyangtis (type of vasculitis)
what are two types of autoimmune liver disease and what are the associated autoantibodies
anti-mitochondrial Ab specific for primary billiary sclerosis
anti-smooth muscle and anti-liver antibodies (LKS) found in autoimmune hepatitis
what is the role of autoantibodies in diagnosis of type 1 DM
give examples of types of DM autoantibodies
disease confirmation
islet cell autoantibodies
anti-GAD65/67, IA-2 and IAA’s
what are examples of future diagnostic test for autoimmune diseases
cytokines in serum
T reg detection
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