Chapter 15 Flashcards
Define immunocompetence
ability of human to mount a normal immune response
which immunity…
discriminate well between self and non-self
adaptive
which immunity…
acts indiscriminately
innate
which immunity…
made up of classes of identical cells
innate
which immunity…
enormous diversity that can recognize trillions of antigens
adaptive
which immunity…
same type of response to each pathogen
innate
which immunity…
is specific, unique resposne to each pathogen
adaptive
which immunity…
remembers previous exposures to antigens to mount stronger subsequent response
adaptive
which immunity…
has no memory of previous exposure
innate
what are two features of adaptive immunity
specificity
memory
define specificity with adaptive immunity
antibodies produced; function only against the antigen that they were produced in response to
Define memory with adaptive immunity
lymphocytes are programmed to “recall” their first encounter with an antigen and respond rapidly to subsequent encounters
adaptive immunity is the product of
dual system of B cells and T cells
define antigens
molecules that are recognized by T cells or B cells
What makes a good antigen
very specific interactions
antigens are complex molecules with
lipoproteins
lipopolysaccharides
nucleoproteins
What makes a poor antigen
small, simple molecule not attached to a carrier molecule and simply large molecules
Innate immunity takes care of
usual suspects
cells of adaptive immune system achieve high specificity and selectivity using a cell surface unique
to single antigen
by the time T and B cells reach lymphoid tissues each one is already equipped to respond to a single unique antigen…
what are the major functions of receptor
- recognize self vs nonself
- phagocytosis
- produce cytokines that function in cell signalling
it is accepted that there is a _________ lymphocyte receptor for each unique antigen
different
What is the clonal selection theory
undifferentiated lymphocytes in embryo and fetus undergo a continuous series of division and genetic changes that generate millions of different cell types, each with a particular unique receptor specificity
progency of B cell clone are called
plasma cells and memory b cells
progeny of T cell clone are called
CD8 cytotoxic t cells