6.13 Spirurid Nematodes Flashcards

1
Q

The Spiruridia order includes what worms

A

spirurids, filarids, guinea worm (Dracunulus)

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2
Q

what is the location of most Spiruridia

A

stomach worms, but also connective tissue and eyes

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3
Q

what is the stomach worm of dogs

A

Physaloptera

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4
Q

what is the stomach worm of dogs and cats

A

Spirocerca

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5
Q

what are the eye worms

A

Thelazia

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6
Q

what are the stomach worms of horses

A

Habronema/Draschia

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7
Q

All Spirurids have (direct/indirect) lifecycles and use ________________ hosts

A

indirect; arthropodan intermediate (also paratenic)

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8
Q

what are the migrations of Spirurids

A

simple (no tracheal or somatic and therefore no vertical transmission)

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9
Q

do Spirurids have a relatively long or short PPP

A

long

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10
Q

what are the intermediate hosts of horse stomach worms (Habronema/Draschia)

A

muscid flies: house flies and stable flies

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11
Q

describe the lifecycle of Habronema/Draschia

A

stable flies or house flies pick up larvae -> L3 or the flies are ingested by the horse -> mucosal migration in the gastric pits produces adults

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12
Q

what is the pathogenesis of Habronema and Draschia

A

Habronema invades the mucosa, causing chronic gastritis

Draschia invades the submucosa, forming tumor-like caseous nodules

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13
Q

T/F the gastritis and tumor-like nodules formed by Habronema and Draschia are responsible for the main disease

A

F; it is the larvae that cause the main burden of disease

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14
Q

Describe the pathogenesis and clinical signs of Habronema/Draschia megastoma

A

occurs in an immune host when flies lay larvae on the skin or conjunctiva that then attempt to migrate -> granulomatous inflammation activated by host -> inflammatory lesion produces sore -> weeping of sore attracts more flies -> propagation of the problem

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15
Q

can Draschia or Habronema be treated? with what?

A

Draschia cannot due to the tumor-like lesions

Habronema can be with moxidectin or ivermectin

Habronema and Draschia in the skin can be treated with ivermectin

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16
Q

what are the general features of all filarid nematodes

A
  • host-specific
  • require a blood-sucking insect as an intermediate host
  • generally infect CT or body cavities
  • long, slender adults
  • have microfilaria (pre-L1) stage
17
Q

describe the pathogenesis and disease caused by Guinea Worm (Dracunulus)

A

adults live in the connective tissues of the legs -> creates hot blistering lesion -> when host puts their leg in water to relief the burning the female contracts uterus to release eggs -> intermediate host takes up eggs within the water -> intermediate host ingested

18
Q

what is the intermediate and definitive host of Acanthocheilonema reconditum

A

fleas; dogs

19
Q

where are adult Acanthocheilonema reconditum found

20
Q

what is the morphology of Acanthocheilonema reconditum
- adults
- microfilaria

A

adults are up to 5cm, slender

microfilaria parallel-sided anterior end

21
Q

describe the lifecycle of Acanthocheilonema reconditum

A

microfilaria in the blood of infected dogs -> fleas ingest microfilaria -> develop to L3 within the flea -> re-enters dog (grooming) -> adults in CT -> microfilaria produced by adults

22
Q

what is the pathogenesis and clinical signs of Acanthocheilonema reconditum

A

non-pathogenic and no clinical signs

23
Q

what are the IH and DH of Dirofilaria immitis

A

IH: mosquitos
DH: dogs, cats, ferrets, wild canids, seals, sea lions, humans

24
Q

what is the location of adult Dirofilaria immitis

A

right caudal lobar artery; other branches of pulmonary arteries; right ventricle in heavy infections

25
Q

what is the morphology of adult and microfilaria Dirofilaria immitis

A

adults: slender, up to 35cm
microfilaria: tapered anterior end

26
Q

how can you tell apart male vs female Dirofilaria immitis

A

males have a curly tail

27
Q

how can you distinguish Acanthocheilonema reconditum and Dirofilaria immitis

A

A. reconditum does not taper at the anterior end whereas D. immitis does; D. immitis makes more serpentine movements

28
Q

what is the life cycle of Dirofilaria immitis

A

microfilaria in blood of host -> mosquito ingests microfilaria -> microfilaria develop to L3 in the mosquito under the correct conditions -> L3 move to the proboscis -> transmitted with next blood meal -> larvae move subcutaneously and lodge in the pulmonary circulation -> mature in the pulmonary arteries

29
Q

what environmental conditions are needed for Dirofilaria immitis to develop in the mosquito

A

above 14 C for at least 7 days

30
Q

when is heartworm transmission season in Canada

A

June - Oct

31
Q

what is the pathogenesis of heartworm (assuming in a patient in an endemic area in the South)

A

arteritis in the pulmonary circulation; dead worms produce thromboemboli in the lung capillaries and arterioles -> inflammation

Overall: increased vascular resistance and pulmonary hypertension

Pulmonary hypertension produces right sided hypertrophy and CHF

Congestion can produce liver damage

32
Q

what is the presentation of heartworm in most dogs in Canada

A

asymptomatic

33
Q

what are the ways to diagnose heartworm

A
  • antigen test
  • Knotts test or Difil test for microfilaria
34
Q

what is an important caveat to the test for heartworm:
- antigen
- microfilaria

A

antigen: most depend on antigen from reproductively active females (will not see if no females, senescent females, single worm infection, or prepatent period)

microfilaria: some dogs amicrofilaremic but infected

35
Q

what are the ways to treat Dirofilaria immitis

A
  • adulticide (Immiticide)
  • surgery
  • microfilaricides (ivermectin, milbemycin)
  • prevention (ivermecin, milbemycin)
36
Q

describe heartworm in cats

A
  • very rare, more common in highly endemic regions
  • more extensive clinical signs with fewer worms (chronic tachypnea, coughing, abnormal lung sounds, vomiting)
  • usually amicrofilaremic