4.5 Pesticides and Rodenticides Flashcards
what is the definition of pesticides
conventional chemical substances, as well as pheremones, organisms and devices that can be used to control a pest or lessen the detrimental effects of a pest
T/F pesticides are usually selective to the pest
F
what two types of insecticides share the same MOA
carbamates and organophosphates (OPs)
what is the MOA of OPs and carbamates
inhibit cholinesterase
how are OPs and carbamates metabolized and excreted
metabolized in the liver to the active form (toxication) and excreted in urine
how do OPs versus carbamates bind to acetylcholinesterase
OPs: irriversible
carbamates: reversible
by inhibiting acetylcholinesterase, what effect do OPs and carbamates have on the nervous system
activation of nicotinic, muscarinic and CNS cholinergic receptors
what are the clinical signs of OP/carbamate poisoning
SLUDGEM
how is OP/carbamate toxicosis diagnosed
history, clinical signs, plasma/whole blood and brain testing for AChE activity, testing of suspect materials, stomach contents, tissues
describe the interpretation of the following AChE activity results:
< 50% of normal:
< 25% of normal:
< 50% of normal: suspect, possible
< 25% of normal: diagnostic
how do we treat OP/carbamate poisoning
supportive care, detoxification (lavage, charcoal), atropine, pralidoxime chloride
T/F OPs and carbamates can negatively affect RBC AChE and plasma BChE activity in agricultural workers, prompting staff relocation
T
what is a very important organochloride historically that is still used today
DDT
what does DDT do to eggs and what is a consequence
thins shell -> decline in bird populations (ex. raptors)
what is the MOA of organochlorides
endocrine disruptors
why were organochlorides mostly banned
they persist in the environment and bioaccumulate
which is more stable and which is more unstable, which is more allergenic?
a) pyrethrins
b) pyrethroid
pyrethrins are more unstable and more allergenic
pyrethroids are more stable
what plant are pyrethrins derived from
Chrysanthenum
what is the MOA of pyrethrins and pyrethroids
slow opening/closing of neuronal Na channels -> continued depolarization -> hyperexcitability
where is there an abundance of Na channels in the body (3)
muscle, salivary gland, CNS
what are some clinical signs of pyrethrin and pyrethroid toxicosis
related to the muscle, salivary gland and CNS (where there is Na channels:
hypersalivation, vomiting, diarrhea, hyperexcitability, ataxia, tremors, seizures, hypo or hyperthermia, paresthesia, hypersensitivity
how do we diagnose pyrethrins/pyrethroid toxicosis
history of exposure, clinical, signs, tissue residues on chromatography