2.1 Red Blood Cells

Question 1

The cytokine that regulates hematopoiesis is called _____________, which is produced by the _______________ in response to ___________

Answer 1

EPO; kidneys; hypoxia

Question 2

what are the cell types (in order) that precurse RBCs

Answer 2

rubriblast -> prorubricyte -> rubricyte -> metarubricyte -> reticulocyte -> erythrocyte

Question 3

once an RBC precursor becomes a ____________ it stops dividing in the bone marrow

Answer 3

metarubricyte

Question 4

the process of erythropoiesis takes

Answer 4

7 days

Question 5

to complete a CBC, what type of tube would you collect blood into and why

Answer 5

purple top (EDTA): CBC requires whole blood sample (plasma); EDTA is an anticoagulant so will prevent coagulation of the sample

Question 6

slight bilirubinemia is normal in what species

Answer 6

horses and ruminants

Question 7

auto-agglutination indicates

Answer 7

underlying disease with an immune-mediated component

Question 8

RBCs lined up in rows like beads on a chain is called

Answer 8

Rouleaux

Question 9

Rouleaux is normal in _____ and ______ but usually indicates ____________ in _______ and _________

Answer 9

horses; healthy cats; elevated protein; dogs; ruminants

Question 10

if you see agglutination and rouleaux present, how would you distinguish what is going on

Answer 10

saline dilution test; if cells no longer adherent it was rouleaux

Question 11

horses NEVER release what from the bone marrow

Answer 11

reticulocytes

Question 12

We call these cells reticulocytes when stained with ________________ and polychromatophils when stained with _______________

Answer 12

New Methylene Blue; Wrights

Question 13

A change in normal RBC shape or appearance is called

Answer 13

poikilocytes

Question 14

A common artifact of RBCs that dried too slowly is

Answer 14

Crenation

Question 15

Crenation indicates

Answer 15

nothing, it is artifact

Question 16

Acanthocytes indicate

Answer 16

underlying liver or spleen disease

Question 17

Target cells indicate

Answer 17

liver disease

Question 18

Hypochromasia indicates

Answer 18

potential iron deficiency

Question 19

Spherocytes indicate

Answer 19

IMHA, immune disease

Question 20

You can only reliably indicate spherocytes in which species

Answer 20

dogs

Question 21

Fragments of RBCs are called

Answer 21

shistocytes