2.1 Red Blood Cells Flashcards
The cytokine that regulates hematopoiesis is called _____________, which is produced by the _______________ in response to ___________
EPO; kidneys; hypoxia
what are the cell types (in order) that precurse RBCs
rubriblast -> prorubricyte -> rubricyte -> metarubricyte -> reticulocyte -> erythrocyte
once an RBC precursor becomes a ____________ it stops dividing in the bone marrow
metarubricyte
the process of erythropoiesis takes
7 days
to complete a CBC, what type of tube would you collect blood into and why
purple top (EDTA): CBC requires whole blood sample (plasma); EDTA is an anticoagulant so will prevent coagulation of the sample
slight bilirubinemia is normal in what species
horses and ruminants
auto-agglutination indicates
underlying disease with an immune-mediated component
RBCs lined up in rows like beads on a chain is called
Rouleaux
Rouleaux is normal in _____ and ______ but usually indicates ____________ in _______ and _________
horses; healthy cats; elevated protein; dogs; ruminants
if you see agglutination and rouleaux present, how would you distinguish what is going on
saline dilution test; if cells no longer adherent it was rouleaux
horses NEVER release what from the bone marrow
reticulocytes
We call these cells reticulocytes when stained with ________________ and polychromatophils when stained with _______________
New Methylene Blue; Wrights
A change in normal RBC shape or appearance is called
poikilocytes
A common artifact of RBCs that dried too slowly is
Crenation
Crenation indicates
nothing, it is artifact
Acanthocytes indicate
underlying liver or spleen disease
Target cells indicate
liver disease
Hypochromasia indicates
potential iron deficiency
Spherocytes indicate
IMHA, immune disease
You can only reliably indicate spherocytes in which species
dogs
Fragments of RBCs are called
shistocytes
