3.4 Cell Division Part 3 Flashcards

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1
Q

What holds sister chromatids together at the centromere?

A

cohesin

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2
Q

What occurs during metaphase?

A

centromeres of chromosomes line up at the equatorial plate/metaphase plate

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3
Q

Where does the metaphase plate lie?

A

completely perpendicular to the line formed by the spindle fibers

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4
Q

What is prometaphase?

A

the movement to the metaphase plate

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5
Q

How do spindle fibers connect to the centromeres of chromosomes?

A

kinetochore

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6
Q

How does the kinetochore associate with the centromere?

A

forming a protein complex on opposite sides of the centromere

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7
Q

Once the chromosomes are lined up at the metaphase plate, what occurs?

A

cohesin is degraded by separase everywhere EXCEPT at the centromere

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8
Q

What protects the centromere from cohesin degradation?

A

family of proteins known as shugoshin

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9
Q

What is the shortest phase of mitosis?

A

anaphase

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10
Q

What happens during anaphase?

A

sister chromatids are separated and pulled to opposite ends of the cell

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11
Q

What is disjunction?

A

when sister chromatids are separated

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12
Q

What are sister chromatids known as after anaphase?

A

daughter chromosome

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13
Q

What does the movement of daughter chromosomes to the respective poles rely on?

A

kinetochore-spindle fiber attachment

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14
Q

What are molecule motors?

A

motor proteins that help drive chromosomes along spindle fibers to their ends of the cell

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15
Q

How do motor proteins get their energy?

A

from ATP

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16
Q

After anaphase, how many chromosomes are there and where are they?

A

46 chromosomes at each pole

17
Q

What occurs during telophase?

A

two complete sets of chromosomes at each end of the cell and the cell pinches into two cells

18
Q

What is the division of the cell known as during telophase?

A

cytokinesis

19
Q

What is the leading cause of cancer?

A

disregulation of the cell cycle

20
Q

What did Hartwell, Nurse, and Hunt do to earn the 2001 Nobel Prize?

A

understanding of the cell cycle and its checkpoints