30/5 Flashcards
What vit deficency is seen in alcoholics and eating disorders?
How does it present?
Vit B3
4Ds for B3
Diarrhoea
Dermatitis - brown scaly rash on neck = casal necklace
Dementia
Death
What is seborrheic dermatitis?
WHAT DAN HAD (Borr = BARRy) - kinda lol
Chronic dry skin in sebum-rich areas (THINK OF DAN)
- treat with ketoconazole and a short course of topical steroids
Transtuzumab
Drug used in breast cancer
Trans = TRANS people = BOOBS
AKA Herceptin
Adenosine or atropine not in asthma?
What is used instead?
adenoSine not in aSthma
verapamil
What electrolyte imbalance is found in refeeding syndrome and explain why?
Refeeding after prolonged starvation
Starvation = drop in insulin and electrolyte levels
Refeeding = increase in insulin to manage new source of food = increase in phosphate uptake into cells = HYPOphophatemia
Low electrolyte levels and HYPERglycemia
What is a normal ABPI vs severe disease?
Normal = 0.9-1.2
Severe = <0.5
Kallmann syndrome
ll = look like the lines coming off a smelly thing = kanny smell
Also has hypogondaism
What med is used in hyperprolocatinemia?
What presentation?
Cabergoline - dopamine agonist
Amenorrhea
Galactorrhoea
Loss of libido
Impotence in men
Explain SIADH findings and why you get them - do some drawings it helps
What is the complication that can occur when corrrecting the salts
Euvolemic (increase in ADH = water retention but not excessively)
Increased water = low Na+ = hyponatremia + low osmolality
Increased salt in urine = high urine osmolaity + high urine Na+
Complications
- “high to low, brain will blow, low to high, pons will die”
- cerebral oedema and central pontine myelinolysis
Autoimmune cause of panhypoputuitirsm?
What needs to be replaced first?
Sheenan - post pregnancy/haemorraghe/poor blood perfusion
Hydrocortisone
How is acromegaly investigated?
Managed?
- IGF-1
- If above positive -> oral glucose tolerance test (failure of suppresion of growth hormone = positive)
Sandostatin = reduces tumour size
DI is a problem with ADH - either cranial (not producing ADH) or nephrogenic (not responding to ADH)
How can you tell the difference?
How is it managed?
Will have high serum osmoality (as peeing out so much) and low urine osmolality (as peeing out so much)
Water deprivation test (no water for 8hrs and then give desmopressin)
- if respond to desmopressin (urine osmolaity increases) = cranial DI
- if not respond to desmopresson = nephrogenic DI
Desmopression meds sometimes work = hard to manage
Most common cause of nephrogenic DI?
Lithium
Diabetes sick rules on insulin
Do not change regime just increase how much you check
Does metformin induced lactic acidosis cause pain?
NO
