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Question 1

What do the incretin drugs (DDP4 inhibitors -gliptin and GLP-1 rec. agonist -tide) put you at increased risk of?

Answer 1

Pancreatitis

Question 2

What do sulphonylureas put pts at increased risk of?

What are the names of these drugs?

Answer 2

Hypos - MUST be warned about this

Gli-ide

Question 3

What is osteomalacia?

What are the symptoms?

How is it managed?

Answer 3

AKA rickets
Due to vit D deficency

Low Ca+ and low phosphate, increased ALP (ALP is used in calcification of bones) and PTH (cause of 2ndary hyperparathyroidism)

Waddling gait, bending bones, easy fractures

Correct vit D deficiency

Question 4

Looser’s zones?

Answer 4

Pseudofractures found in osteomalacia

Question 5

What is Paget’s disease?
Who gets it and how does it present?

What can it look like on XR?

What can be seen on bloods?

Management?

Answer 5

Disorder of osteoblasts (bone secreting) - creates sclerotic thickened bone

Men - late adulthood

Bony pain (spine and pelvis in particular), abnormally big head

Flame shaped lesion along the shaft of bone

Isolated raised ALP

Bisphosphnates (bone turnover supressor)

Question 6

Pepper-pot skull

Answer 6

Hyperparathyroidism