19. Immunisation Flashcards

1
Q

What is an antigen?

A

Live or inactivated substance capable of producing an immune response

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2
Q

What is an antibody?

A

Immunoglobulin produced by B cells to help eliminate an antigen

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3
Q

What is an adjuvant?

A

Substance that increases the antibody response

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4
Q

Name 2 adjuvants

A

Aluminium phosphate

Aluminium hydroxide

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5
Q

What is immunisation?

A

Process of artificially inducing or providing immunity to an infectious disease

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6
Q

What indicates how successful a vaccine is?

A

Presence of antibodies

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7
Q

What is passive immunity?

A

Injection of antibodies

Immediate but short lived protection

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8
Q

Name 2 forms of passive immunity

A

Post Exposure Prophylaxis

Transplacental

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9
Q

What is active immunity?

A

Stimulates host production of immune response

May be live or non live

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10
Q

Name the forms of non-live vaccines

A

Whole inactivated
Protein based
Polysaccharide based
Recombinant

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11
Q

How is a whole inactivated vaccine created?

A

Pathogen is killed by heat or formalin

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12
Q

How many doses are needed for a whole inactivated vaccine?

A

3-5

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13
Q

What sort of response is generated by a whole inactivated vaccine?

A

Humoral

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14
Q

Name 2 whole inactive vaccines

A

Polio

Hep A

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15
Q

What vaccines are live and must not be given to immune compromised patients?

A

BCG
MMR
Varicella

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16
Q

What are the 2 forms of protein-based vaccine?

A

Toxoid

Subunit

17
Q

What is a toxoid vaccine?

A

Bacterial toxin modified so it is antigenic but not toxigenic

18
Q

Name 2 toxoid vaccines

A

Diptheria

Tetanus

19
Q

What is a subunit vaccine?

A

Contains antigenic proteins of the infectious agent

20
Q

Name a subunit vaccine

A

Pertussis

21
Q

Name the 2 types of polysaccharide based vaccines

A

Pure

Conjugate

22
Q

What is a pure polysaccharide vaccine?

A

Polysaccharide from bacterial capsule

23
Q

Name a pure polysaccharide vaccine

A

Pneumococcal

24
Q

What is a conjugate polysaccharide vaccine?

A

Polysaccharide is linked to a protein

This provides a greater immune response

25
Q

Name 2 conjugate polysaccharide vaccines

A

Hib

MenACWY

26
Q

What is a recombinant vaccine?

A

DNA is taken from the pathogen and inserted into bacterial and yeast cells which produce an active ingredient from the vaccine

27
Q

Name 2 recombinant vaccines

A

HepB

HPV

28
Q

What are the contraindications for giving a vaccine?

A

Previous anaphylaxis
Live vaccines carry a risk in pregnant and immune compromised
Don’t give rotovirus vaccine to those over 8 months old
Current acute febrile illness
Recent Ig (passive immunity)