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FIM > 16. b. Bordetella > Flashcards

16. b. Bordetella Flashcards

1
Q

What disease is caused by bordetella pertussis?

A

Whooping cough

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2
Q

Reinfection is possible for whooping cough. T/F?

A

False

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3
Q

What groups is a booster vaccine recommended for?

A

Age 11-14
Healthcare workers
Pregnant women

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4
Q

What virulence factors help bordetella pertussis to adhere to respiratory cells?

A

Filamentous haemaglutinin
Pertactin
Fimbriae

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5
Q

What toxins are produced by bordetella pertussis?

A

Tracheal cytotoxin
Pertussis toxin
LPS endotoxin

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6
Q

What effect does tracheal cytotoxin have?

A

Paralyses cilia and causes coughing fits

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7
Q

What mode of transmission is present in bordetella pertussis?

A

Droplet

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8
Q

What causes low O2 saturation in whooping cough?

A

Bronchioles become blocked with inflammatory cells, lymphocytes and mucous
Causes alveolar collapse

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9
Q

What are the 3 stages of Whooping cough?

A

Catarrhal stage
Paroxysmal stage
Convalescent stage

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10
Q

How long does each stage last?

A

Catarrhal: 1-2 weeks
Paroxysmal: 2-4
Convalescent: 3-4

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11
Q

What are symptoms of whooping cough during the catarrhal stage?

A

Non-specific cold symptoms

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12
Q

What are symptoms of whooping cough during the paroxysmal stage?

A

Severe cough followed by a whoop on inspiration

Post-tussis vomiting

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13
Q

What does bordetella pertussis look like under the microscope?

A

Very small gram negative coccobacillus

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14
Q

How many serotypes of bordetella pertussis are there?

A

3

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15
Q

Is bordetella pertussis aerobic or anaerobic?

A

Aerobic

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16
Q

Is bordetella pertussis encapsulated?

A

Yes

17
Q

When should BP be suspected?

A

Any cough that lasts more than 2 weeks

18
Q

How could BP be detected via blood test?

A

Increased lymphocytes

19
Q

What samples can be sent to the lab?

A

Pernasal

Serum

20
Q

What complications can arise from BP?

A

Pneumonia
Seizures
Encephaltopathy
Death

21
Q

What culture will BP grow on?

A

Charcoal blood agar

22
Q

How is BP detected in serology?

A

Anti-pertussis IgG detected after 2 weeks of onset of symptoms

23
Q

What treatment can be given for Whooping cough?

A

Supportive, ICU if needed

Erythromycin or clarithromycin can be given during the catarrhal stage

24
Q

What type of vaccine is used to prevent whooping cough?

A

Acellular vaccine

Has antigen to virulence factors

25
Q

Why is an acellular vaccine given instead of a whole cell vaccine?

A

Has less reactions

FIM (44 decks)

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