17 - Bacterial Pathogenesis Flashcards
Bacteria which commonly have afimbrial adhesins
G- bacteria (as are often inserted in outer cell membrane)
Proportion of microbiome that is in large intestine
~70%
Protein that ETEC uses to bind to human intestinal epithelium
CS3
Experiment looking at ETEC virulence in piglets
Without K88 adhesin, there was no ETEC adhesion to intestinal wall, an no pathogenesis, even in E coli that were toxin+ (no diarrhoea)
How can piglets be immunised?
Immunise sow, when piglets suckle milk get sow’s IgA
Travelan
Antibodies against ETEC.
Treats traveller’s diarrhoea
Where do yersinia enter intestinal wall?
Through M cells
Which protein does yersinia use to enter M cells?
Invasin
What does yersinia invasin bind to?
Integrin on M cell
What are pyogenic bacteria?
Pathogenic bacteria that evade phagocytosis, resulting in pus formation
Example of bacterium which produces leukocidins
S pyogenes, S aureus
Example of a bacterium that produces an anti-inflammatory
Choleratoxin is an anti-inflammatory agent
Number of S. pneumoniae capsular antigens
Around 90
Is there any cross-reactivity between Ig against S. pyogenes capsules?
No
Adult pneumococcal vaccine
23 most-common S. pyogenes capsular antigens
Children’s’ pneumococcal vaccine
13 most-common S. pyogenes capsular antigens