123 - Antiemetic, Antidiarrhoeal Drugs Flashcards
Example of a D2 antagonist
Metaclopramide
Metaclopramide effects
Increases contractions in upper GIT, which makes stomach empty more quickly.
5HT4 receptor stimulation -> ACh release (Metaclopramide).
Metaclopramide also has dopaminergic effects. Blocks dopamine in the gut.
D2 antagonist
Is metaclopramide a reversible or irreversible antagonist?
Reversible.
If taken long-term, D2 antagonists can have permanent effects (severe side effects - extrapyramidal side-effects - uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs)
Example of a 5HT3 antagoinst
Ondansetron
Ondansetron side effects
Constipation.
Headaches.
What are metaclopramide and ondansetron used to treat?
Nausea, vomiting
Endogenous compound that stimulates NK1 receptors
Substance P
Example of a neurokinin-1 receptor antagonist
Aprepitant
How is aprepitant administered?
Always in combination with another drug
Example of two add-on drugs for nausea, emesis
1) Aprepitant
2) Dexamethasone (glucocorticoid)
What are neurokinin-1 receptor antagonists used for?
Anti-emetic
Bulking agents
Hydrophilic colloids.
Indigestible vegetable fibre that increases faecal water retention, therefore increasing volume of faeces.
Increases normal reflex bowel activity.
Examples of bulking agents
Bran, Psyllium, Ispaghula husk, Sterculia.
Psyllium is the most important to remember
Side effects of bulking agents
Water loss.
If constipation is slow-transit, or is opioid-induced, can just contribute to faecal mass, increase impaction.
Increased flatulence.
Does chronic use of stimulant laxatives cause an atonic colon?
Maybe causes permanent atonia of colon, but it is not clear