123 - Antiemetic, Antidiarrhoeal Drugs Flashcards

1
Q

Example of a D2 antagonist

A

Metaclopramide

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2
Q

Metaclopramide effects

A

Increases contractions in upper GIT, which makes stomach empty more quickly.

5HT4 receptor stimulation -> ACh release (Metaclopramide).

Metaclopramide also has dopaminergic effects. Blocks dopamine in the gut.

D2 antagonist

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3
Q

Is metaclopramide a reversible or irreversible antagonist?

A

Reversible.
If taken long-term, D2 antagonists can have permanent effects (severe side effects - extrapyramidal side-effects - uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs)

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4
Q

Example of a 5HT3 antagoinst

A

Ondansetron

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5
Q

Ondansetron side effects

A

Constipation.

Headaches.

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6
Q

What are metaclopramide and ondansetron used to treat?

A

Nausea, vomiting

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7
Q

Endogenous compound that stimulates NK1 receptors

A

Substance P

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8
Q

Example of a neurokinin-1 receptor antagonist

A

Aprepitant

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9
Q

How is aprepitant administered?

A

Always in combination with another drug

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10
Q

Example of two add-on drugs for nausea, emesis

A

1) Aprepitant

2) Dexamethasone (glucocorticoid)

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11
Q

What are neurokinin-1 receptor antagonists used for?

A

Anti-emetic

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12
Q

Bulking agents

A

Hydrophilic colloids.
Indigestible vegetable fibre that increases faecal water retention, therefore increasing volume of faeces.
Increases normal reflex bowel activity.

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13
Q

Examples of bulking agents

A

Bran, Psyllium, Ispaghula husk, Sterculia.

Psyllium is the most important to remember

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14
Q

Side effects of bulking agents

A

Water loss.
If constipation is slow-transit, or is opioid-induced, can just contribute to faecal mass, increase impaction.
Increased flatulence.

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15
Q

Does chronic use of stimulant laxatives cause an atonic colon?

A

Maybe causes permanent atonia of colon, but it is not clear

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16
Q
Four groups of laxatives 
1
2
3
4
A

1) Bulking agents
2) Faecal softeners and lubricants
3) Osmotic laxatives
4) Stimulant laxatives

17
Q

Example of a faecal softener and lubricant

A

Docusate.

18
Q

Docusate
1
2
3

A

Faecal softener and lubricant.
Frequently prescribed for people on opioids.
A detergent, so increases mixture of water into faeces.

19
Q

Danger of using paraffin wax for constipation

A

Can adsorb fat-soluble vitamins.

Can be accidentally inhaled, cause issues in the lungs.

20
Q
Types of osmotic laxatives
1
2
3
4
A

1) Saline laxatives
2) Disaccharide hydrophilic colloid
3) Polyols
4) Macrogols or polyethylene glycols

21
Q

Example of an osmotic laxative

A

Magnesium salts (a saline laxative)

22
Q

How do disaccharide (galacto-fructose) hydrophilic colloids work?

A

Draw water into faeces through osmosis

23
Q

Which laxative is included in some confectionary as an artificial sweetener?

A

Polyols

24
Q

Most-potent laxatives

A

Stimulant laxatives

25
Q

How do stimulant laxatives work?

A

Precise mode of action is not known but may stimulate colonic myenteric nerve plexuses,
irritate intestinal mucosa or by direct sensory nerve ending irritation → increase motility.
May also reduce net reabsorption of water and electrolytes.

26
Q

Example of a stimulant laxative

A

Senna

27
Q

Another name for stimulant laxative

A

Irritant laxative

28
Q

Types of antidiarrhoeal drugs
1
2
3

A

1) Opioids
2) Musculotropic antispasmodic
3) Muscarinic R antagonists

29
Q

Example of an opioid used to reduce diarrhoea

A

Loperamide

30
Q

How do opioid antidiarrhoeals work (basically)

A

Antagonise mu opioid receptors, blocking ACh release.

31
Q

Why doesn’t loperamide cause the CNS effects of other opioids?

A

Doesn’t cross blood brain barrier

32
Q

Musculotropic antispasmodic

A

Mebeverine

33
Q

Example of a muscarinic R antagonist

A

Hyoscine butylbromide

34
Q

Anti-flatulence drug

A

Simethicone

35
Q

Simethicone effect

A

Defoaming polymer, that changes surface tension of small gas bubbles, allowing them to join into larger gas bubbles which can be passed more easily.