Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

mt > WBC > Flashcards

WBC Flashcards

1
Q

Is the orderly production of mature granulocytes (N,E,B)

A

GRANULOCYTE PRODUCTION

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

days of maturation sequence

A

about 14 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

normal range of wbc in full term infant

A

10,000-25,000/uL of blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

normal range of wbc in infants up to 1 yr of age

A

6,000-16,000/uL of blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

normal range of wbc in adults

A

4,000-11,000/uL of blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

detection of changes in. numbers of circulating WBCs

A

differential wbc count

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what does differential wbc count indicates

A

indicates infection, poisoning, leukemia, chemotherapy, parasites or allergy reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

normal wbc counts

A

N = 60-70%
L = 20-25%
M = 3-8%
E = 2-4%
B = <1%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

wbc counts is up if..

A

N = bacterial infection
L = viral infection
M = fungal/viral infection
E = parasitic or allergy reaction
B = allergy or hypothyroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

normal values of WBC count

A

5,000-10,000/cu mm or 5-10 x 10^9/L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

differential count normal valaues

A

N = 50-70% (segmenter 50-65% ; stab 0-5%)
L = 20-40%
M = 2-6%
E = 0-3%
B = 0-1%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

15-20um in size
round/slightly oval shape
fine chromatin
2-5 nucleoli
basophilic cytoplasm staining
none cytoplasm granules
4:1 N/C ratio

A

myeloblast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

15-21 um in size
oval/round shape
slightly coarse chromatin
2-3 nucleoli
basophilic cytoplasm staining
primary granules
3:1 to 2:1 N/C ratio

A

promyelocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

12-18 um in size
oval/round
coarse and condense chromatin
no nucleoli
basophilic acidophilic cytoplasm
secondary granules
1:1 N/C ratio

A

myelocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

10-15 um in size
kidney/indented shape
coarse and clumped
no nucleoli
beigle/salmon cytoplasm staining
many cytoplasm granules
1:1 N/C ratio

A

Metamyelocyte/juvenile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

9-15 um in size
elongated/band (C/s) in shape
coarse and clumped chromatin
no nucleoli
beige/salmon cytoplasm staining
faint granules
1:1/1:2 N/C ratio

A

band/stab/staff

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

9-15 in size
2–5 lobes in shape
highly condensed
no nucleoli
beige/salmon cytoplasm staining
pink-rose violet granules
1:2 N/C ratio

A

neutrophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

9-15 um in size
2 lobes in shape
condensed chromatin
no nucleoli
beige/salmon
reddish-orange granules
1:2 N/C ratio

A

eosinophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

10-16 um in size
unsegmented/ bi lobed shaped
condensed chromatin
none
beige/salmon
dark purple/blue black granules
1:2 N/C ratio

A

basophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

1st recognizable in granulocytic series

A

Myeloblast-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

first appearance of primary granules

A

promyelocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

first appearnce of secondary granules

A

Myelocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

youngest stage

A

metamyelocyte/juvenile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Youngest cell to appear in peripheral blood

A

Band/stab/staff

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

mature granulocytes

A

Neutrphil, Eosinophil, Basophil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

secondary or specific granules in neutrophil

A

Aminopeptidase, collagenase, muramidase, lactoferrin, lysozyme, basic proteins, plasminogen activator, Alkaline phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Larger granules;major basic proteins in Eosinophil

A

Acid hydrolase, peroxidase, phospholipase, cathepsin, Eosinophilic, Cationic CHON, Eosinophil-derived neurotoxin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Smaller Granules in eosinophil

A

Arylsulfatase, Peroxidase, Acid phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

secondary or specific granules in basophil

A

Histamine, Heparin, Peroxidase, Eosinophilic Chemotactic Factor A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Granules: pink-rose violet granules

A

neutrophil/pmn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Mature neutrophil, ratio of primary to secondary granules is

A

2-3:1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

____ together with ____ and ___ kills bacteria

A

Myeloperoxidase (MPO) together with Hydrogen peroxide and halide kills bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Present in primary and 2ndary granules degrades glycopeptides & hydrolyzes carbohydrates of the bacterial cell wall

A

Lyzozyme or Muramidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Fe binding glycoproptein competes with bacteria for Fe (possibly inhibiting growth) and may promote PMN adherence to endothelial cells

A

Lactoferrin

32
Q

neutrophil life span

A

9-10 days

33
Q

where neutrophil production and maturation takes place

A

bone marrow

34
Q

mitotic pool is consists of..

A

myeloblast, promyelocyte & myelocyte

35
Q

maturing pool is consists of..

A

metamyelocyte

36
Q

storage pool is consists of..

A

metamyelocyte, bands and segmented PMN’s

37
Q

50% of PMNs circulating freely

A

circulating pool

38
Q

in marginating pool, 50% of PMNs..

A

50% PMN adhere to the vessel walls or are sequestered in the capillaries.

39
Q

Responds to parasitic and helminthic infection and allergy

A

Eosinophil

40
Q

the concentration of eosinophil is normally hight at

A

night or afternoon

41
Q

granules of eosinophil

A

reddish-orange w/ affinity for eosin (acidic)

42
Q

rich protein that plays a major role in killing parasites

A

arginine

43
Q

2 major function of eosinophil

A
  • Defense against helminthic parasites
  • Has role in allergic reactions by lessening hypersensitivity reactions through the release of an amine oxidase, w/c neutralizes histamine.
44
Q

neutralized histamine

A

amine oxidase

45
Q

Formed from disintegration of eosinophils

A

charcot-leyden crystal

46
Q

charcot-leyden crystal is made up of

A

lysophospholipase

47
Q

lysophoslipase is found in

A

cytoplasm of eosinophils

48
Q

charcot-leyden crystal is seen in:

A

Allergic asthma (nasal mucus)
Pulmonary eosinophilic infiltrates (pleural fluid)
Parasitic infection (stool)

49
Q

Respond to allergic or hypersensitivity reactions

A

Basophil

50
Q

granules of basophil

A

water-soluble blue black specific granules with affinity to methylene blue

51
Q

basophil function

A

Involved in hypersensitivity reactions, such as allergic asthma and delayed-onset allergy reactions

52
Q

10-18 um in size
Coarse chromatin
Round/oval
w/ 1-2 nucleoli
No granules
Appears smooth
Moderate –dark blue

A

lymphoblast

53
Q

Same size as lymphoblast or smaller
More clumped chrom
Round/oval
w/1-2 nucleoli
Non-granular
Mod. –dark blue

A

pro-lymphocyte

54
Q

8-10 um in size
Dense chromatin
round/oval
Nucleoli not visible
Thin rim around nucleus
Robin’s egg blue

A

mature small lymphocyte

55
Q

10-12 um in size
Chrom not as dense as small lymphocyte
More abundant
Pale-mod. blue

A

mature medium lymphocyte

56
Q

12-16 um in size
Round/oval
Nucleoli not visible
Abundant
Clear, very pale blue

A

mature large lymphocyte

57
Q

3 types of lymphocytes

A

T- lymphocytes
B- lymphocytes
Null lymphocytes

58
Q

cellular-mediated immunity

A

t-lymphocytes

59
Q

percent of t-lymphocytes

A

60-80%

60
Q

t-lymphocytes is long lived for __ years

A

4-10 years

61
Q

humoral-mediated immunity

A

b-lymphocytes

62
Q

percent of b-lymphocytes

A

10-20%

63
Q

b-lymphocytes is ___ lived

A

short lived

64
Q

tumor host defense

A

null lymphocytes

65
Q

percent of null lymphocytes

A

10% lymphoid population

66
Q

18-25 um in size
Eccentric (off center)
Basophilic
Abundant
Non granular

A

plasmablast

67
Q

15-25 um in size
eccentric
intensely basophilic

A

proplasmacyte

68
Q

8-20 um in size
Eccentric
Exhibits cartwheel appearance
Deeply basophilic
Mod. Abundant
Large, well-defined hof/perinuclear halo
Non granular

A

plasmacyte/plasma cell

69
Q

15-20 um in size
Round w/ folding & clefting
1-2 nucleoli
Basophilic
Non-granular
4:1 to 3:1

A

monoblast

70
Q

14-18 um in size
Oval, indented or folded
Blue-gray cytoplasm
3:1-2:1

A

promonocyte

71
Q

14-20 um in size (largest cell)
Round, kidney-shaped,maybe folded, showing brain like convolutions
No nucleoli visible
Blue-gray cytoplasm
Many fine azurophilic granules appearing as ground glass (frosted)
2:1-1:1

A

monocyte

72
Q

The tissue component of the monocyte system

A

macrophage

73
Q

macrophages is larger than monocytes and measures

A

15 to 80 um

74
Q

macrophages have ____ cell membrane, often with

A

Have irregular cell membrane, often with blebs and psuedopodia

75
Q

shape of nucleus of macrophages

A

Oblong/indented nucleus

76
Q

Functions of Monocytes and Macrophages

A

Defense against microorganisms

Role in antigen-induced blast transformation of lymphocytes

Destruction of aged blood cells, denatured plasma proteins and lipids

W/heme oxidase activity w/c enables tissue macrophage to break down RBC Hb and recycle it

77
Q

monocyte secrete ______ that activates helper cell

A

lymphokine activating factor

78
Q

a high number of wbcs is called

A

leukocytosis

79
Q

leukocytosis is may be due to

A

Anemia
Certain drugs or medications
Cigarette smoking
Infections (bacteria)
Inflammatory disease (rheumatoid arthritis or allergy)
Leukemia
Sever mental or physical stress
Tissue damage (burns)

80
Q

drugs that may lower WBC count

A

Antibiotics
Anticonvulsants
Anti thyroid drugs
Arsenicals
Captoprill
Chemotherapy drugs
Chlorpromazine
Clozapine
Histamine-2 blockers
Sulfonamides
Terbinafine
Ticlopidine

81
Q

drugs that may increase WBC counts

A

Beta adrenergic agonists (albuterol)
Corticosteroids
Epinephrine
Granulocyte colony stimulating actor
Heparin
Lithium

mt (54 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions