HEMOGLOBIN Flashcards
found in the rbc of the body
hemoglobin
each rbc contains approximately ____ hemoglobin molecules
280 million hemoglobin molecules
main function of rbc
transport of oxygen from the lungs to the body’s cell
rbc contains a protein called
hemoglobin
carries oxygen
hemoglobin
hemoglobin molecule is composed of a protein group, known as
globin
hemoglobin have __ heme groups, associated with an iron atom.
4 heme groups
1 heme = ___ of oxygen and 1 hemoglobin molecule = ____ of oxygen
1 mole of oxygen ; 4 moles of oxygen
in synthesis of hb molecule, the heme portion begins..
Heme Portion: begins in the mitochondria with the formation of D-ALA from glycine and succinyl coenzyme A
in synthesis of hb molecule, the globin portion begins..
Globin portion: produced on specific ribosome in the cytoplasm of the red blood cells
The globin in each hemoglobin molecule consists of ___ polypeptide chains which
determine the type of hemoglobin formed.
four
Gene involved for Alpha & Zeta chains:
chromosome 16
Gene involved for Beta, Delta, Epsilon & Gamma chains:
chromosome 11
hb in Adult
HbA1 > 95%
HbA2 1.5-3%
HbF <2%
hb in neonate
-HbF 60-80%
-HbA 20-40%