Unit 9 - CAD Flashcards
coronary artery disease is cause by impaired blood flow to _____
myocardium
chest pain caused by reduced cardiac blood flow
angina pectoris
unstable cardiac ischemia
acute coronary syndrome (ACS)
necrosis/death of myocardial cells
acute myocardial infarction (AMI)
Pathophysiology/etiology of CAD:
- blood flow in coronary arteries regulated by aortic pressure, heart rate, other factors
- large arteries not connected: small arteries joined by _____ channels -> alternate routes for blood flow
collateral
most common cause of reduced coronary blood flow
atherosclerosis
high levels of low-density lipoprotein (LDLs) and toxins lead to arterial endothelial layer damage and plaque formation
atherosclerosis
complex lesions of lipids, fibrous tissue, collagen, calcium, cellular debris, capillaries - develop -> can rupture or ulcerate causing emboli or thrombus
atheromas
where does atherosclerosis develop
where arteries bifurcate or branch
ischemia develops when…
oxygen supply inadequate to meet metabolic needs
acute coronary syndrome
- coronary blood flow _____ but not entirely occluded
- rupture or erosion of _____ plaque (predominant cause)
- coronary artery _____
- progressive vessel _____
- _____ of coronary artery
- _____ myocardial oxygen demand and/or _____ supply
- ECG changes: inversion of T-wave, possible elevation of _____ segment
- coronary blood flow reduced but not entirely occluded
- rupture or erosion of atherosclerotic plaque (predominant cause)
- coronary artery spasm
- progressive vessel obstruction
- inflammation of coronary artery
- increased myocardial oxygen demand and/or decreased supply
- ECG changes: inversion of T-wave, possible elevation of ST segment
acute myocardial infarction (MI) occurs when blood flow to a portion of cardiac muscle is completely _____, resulting in a prolonged tissue _____ by damages area of the heart
blocked
ischemia
MI:
occlusion L anterior descending artery =
anterior MI
MI:
left circumflex artery =
lateral MI
MI can result from acute cocaine _____
toxicity
angina classes:
I
II
III
IV
Angina class:
does not occur with ordinary physical activity
Class I
Angina class:
prolonged walking or stair climbing
Class II
Angina class:
limits normal activities of daily living
Class III
Angina class:
angina with rest or activity
IV
substernal or epigastric chest pain =
acute coronary syndrome
- continuous chest pain
- onset sudden; not precipitated by activity
- accompanied by nausea, vomiting, hypotension, bradycardia
acute myocardial infarction