UNIT 11 Phosphodiesterase (PDE) inhibitor

Question 1

What is the drug class of Sildenafil

A. Phosphodiesterase (PDE) inhibitor
B. Glycopeptide
C. Androgen
D. NSAID

Answer 1

A. Phosphodiesterase (PDE) inhibitor

Question 2

What is the use of Sildenafi

Answer 2

Sildenafil
Action

 Increases blood flow to the penis
Uses
 Erectile dysfunction
 Benign Prostatic Hypertrophy
 All drugs in this class end in fil

Question 3

Should you take nitroglycerin with Sildenafil

Answer 3

NO

Contraindications
* Significant cardiovascular disease
* History of priapism- a disorder in which the penis maintains a prolonged, rigid erection in the absence of appropriate stimulation

• Caution – other antihypertensives & heart medications
• Interactions
• Nitroglycerin
• Cannot be taken together. If taking or on prn NTG, it cannot be used within 24
  hours (or more depending on liver/kidney function)
• Grapefruit juice – increases action of sildenafil and S/E and A/

Question 4

Side effects of Sildenafil

Answer 4

Side Effects/Adverse Reactions
* Headache, nasal congestion
* GI upset
* GU issues
* Photosensitivity

Question 5

The nurse teaches a patient that sildenafil is contraindicated for
patients taking which category of medications?
A. Sulfonylureas
B. Beta blockers
C. Nitrates
D. Proton pump inhibitors

Answer 5

C. Nitrates

Question 6

Which drug used in the treatment of benign
prostatic hypertrophy is most likely to cause
postural hypotension?
A. Tamsulosin
B. Dutasteride
C. Finasteride
D. Testerone

Answer 6

A. Tamsulosin