UNIT 11 Antidiarrheal – Opiate with Anticholinergic

Question 1

What is the drug class of Diphenoxylate with atropine

Answer 1

Antidiarrheal – Opiate with Anticholinergic

Question 2

action of Diphenoxylate with atropine

Answer 2

Action
 Inhibits gastric motility by slowing peristalsis
 Combination weak opioid and anti-cholinergic

 Uses
 Treat diarrhea

Question 3

Side effects/ Diphenoxylate with atropine

Answer 3

Side effects/
 Contains the side effects of opioids and anti-cholinergic
Dry mouth
Constipation

Drowsiness, dizziness, euphoria, headache, restlessness, abdominal pain, nausea, vomiting, constipation, dry mouth, anorexia

Question 4

can you use Diphenoxylate with atropine with a patient with glaucoma

Answer 4

no

Question 5

Adverse effect of Diphenoxylate with atropine

Answer 5

 Long-term use – paralytic ileus

Angioedema, pancreatitis Life-threatening: Ileus, toxic
megacolon, anaphylaxis, respiratory depression

Question 6

Contraindications of Diphenoxylate with atropine

Answer 6

Contraindications/interactions
 Similar to opioids and anti-cholinergic
 No CNS depressants
 No glaucoma
 C. Diff or other infectious diarrhea

Question 7

Would you use Diphenoxylate with atropine for a patient with C. diff

Answer 7

No

Question 8

Is this drug a CNS depressant

Answer 8

Yes

Angioedema, pancreatitis Life-threatening: Ileus, toxic
megacolon, anaphylaxis, respiratory depression

Question 9

Nursing Intervention for Antidiarheals

Answer 9

Interventions/teaching
 Monitor VS
 Monitor fluid/electrolyte status
 Notify HCP if diarrhea continues longer than 48 hours
or acute abdominal pain occurs
 Do not take with CNS depressants
 Take medication as prescribed
 Drink a lot of fluids
 No fried foods or milk products
 Constipation can result from overuse
Nursing process: antidiarrheals