UNIT 10 Antifungal

Question 1

What type of infections does Antifungals treat?

Answer 1

superficial infections
* Oral candidiasis (thrush)
* Vaginal candidiasis (yeast infection)
* Tinea pedis (athlete’s foot

Question 2

2 Antifungal drugs

Answer 2

Nystatin- swish or spit swish or swallow (topical or lotion) LOCALIZED

Fluconazole – systemic – oral tablet, IV

Question 3

Nystatin use

Answer 3

Nystatin
Methods of administration: oral, topical
Used for fungal superinfections (yeast infections)
Patient teaching
* Candidiasis - Administration: Swish and swallow
– Gargle if throat affected
* Apply a thin layer topically

Question 4

Flucanozole use

Answer 4

fluconazole
Treat
More severe systemic fungal infections
Also ordered for vaginal yeast infections
Route
* Oral, vaginal, topical, IV

Question 5

side effect flucvonazole

Answer 5

GI upset (e.g., nausea, vomiting, diarrhea, abdominal pain, dyspepsia), rash, headache, hypokalemia

Question 6

adverse effect flucanzole

Answer 6

Hepatotoxicity, seizures, leukopenia, agranulocytosis, thrombocytopenia, Stevens-Johnson syndrome, QT prolongation, renal failure, fatal cardiac arrhythmias, toxic epidermal necrolysis

Question 7

side effect nystatin

Answer 7

PO: Diarrhea, nausea, vomiting, abdominal pain
Top: Contact dermatitis

Question 8

adverse effect nystatin

Answer 8

Top/susp: Hypersensitivity reaction Life-threatening: PO/top/susp: Stevens-
Johnson syndrome

Question 9

Fluconazole contraindications

Answer 9

Contraindications
Pregnancy
Interactions
Increase bleeding with warfarin
Increase hypoglycemia when taken with sulfonylurea