UNIT 11 Miscellaneous Antiemetic

Question 1

What is the drug class of Metoclopramide

Answer 1

Miscellaneous Antiemetic

Question 2

Action of Metocloperamide

Answer 2

 Action
 Blocking dopamine receptors in the CTZ
 Increases GI emptying
 Uses
 Treatment of postoperative emesis, cancer
chemotherapy, and radiation therapy

For prevention and treatment of postoperative and chemo-induced nausea and vomiting, diabetic gastroparesis, and GERD. Avoid alcohol and CNS depressants. May cause drowsiness, dizziness, dysgeusia, fatigue, restlessness, headache, nausea, and vomiting. PB: 30%; t1⁄2: 2.5–6 h

Question 3

Side effects of Metocloperamide

Answer 3

May cause drowsiness, dizziness, dysgeusia, fatigue, restlessness, headache, nausea, and vomiting

Question 4

Patient Teaching and Contraindications

Answer 4

 High doses can cause sedation and diarrhea.
 Occurrence of EPS is more prevalent in children than in
adults.
 Contraindicated with GI obstruction, hemorrhage, or
perforation
 No alcohol or other CNS depressants