THROMBOLYTIC UNIT 6 CHAPTER 40 Flashcards
Which of the following drugs is an Thrombolytic?
A. Vitamin K
B. Acetominophen
C. Alteplase
D. Amiodarone
C. Alteplase
What is the action of Alteplase and use?
Action
Promotes conversion of plasminogen to
plasmin. Degrades fibrinogen, fibrin and other
clotting factors, which disintegrates the clot
Uses
To dissolve clots following acute MI,
pulmonary embolism, and ischemic stroke
and DVT
All end in ase
What is the side effect of Alteplase?
Epistaxis, infection,
ecchymosis, nausea, vomiting, rash
What is the adverse effect of Alteplase
adverse reactions
Anaphylaxis
Hemorrhage
Anaphylactoid reactions, laryngeal edema, angioedema; cholesterol microembolization, bleeding, hypo/hypertension, GI bleeding, MI, cerebral edema, rhabdomyolysis, bradycardia, tachycardia, heart failure, intracranial hemorrhage, seizures
What should you monitor for with a patient taking Alteplase?
BLEEDING
Should a patient take Alteplase with NSAIDS
?
A. NO
Contraindications
Bleeding
Recent surgery or trauma
Severe liver dysfunction
Head trauma
Interactions
Other drugs and herbs that cause bleeding (NSAIDS)
Nursing Interventions for a patient taking Alteplase?
Inverventions
Monitor vital signs
Labs
CBC
PT/INR – warfarin
PTT – heparin
All – alteplase
Monitor for bleeding-remember the sites from unit 2
Soft toothbrush, electric razor
Have antidote available – heparin, warfarin
Monitor for S/S of allergic reaction
Avoid any venipuncture as able
PATIENT TEACHING FOR ANTICOAG, ORANL ANTICOAG, LOW MOLECULAR WEIGHT HEPARIN, AND THROMBOLYTICS
Teaching
To signs and symptoms of bleeding to report
Use soft toothbrush, electric razor
Inform dentist of medication
Advise of lab draws and importance
Medic alert bracelet
Stop smoking
No NSAIDS or other drugs that cause bleeding
Caution with herbal products
How to stop bleeding
Diet – maintain consistent amount of vitamin K for
warfarin
Evaluation
