ANTIDEPRESSANTS UNIT 3

Question 1

What antidepressant group is Fluoxetine

Answer 1

SSRI - Fluoxetine
◦ Side effects/adverse reactions
◦ Headache, nervousness
◦ Blurred vision, insomnia
◦ Dry mouth, GI distress
◦ Sexual dysfunction
◦ Side effects often decrease over 1 to 4 weeks

ADVERSE EFFECT
◦ Suicidal ideation
◦ Seizures
◦ Hypoglycemia

Question 2

SSRI - Fluoxetine
◦ Contraindications

Answer 2

SSRI - Fluoxetine
◦ Contraindications
◦ Allergy
◦ Caution
◦ MAOI’s, breastfeeding, suicidal, liver or kidney disease,
glaucoma
◦ Interactions
Increased sedation with alcohol and other CNS depressants
Grapefruit juice with SSRIs can lead to toxicity – limit intake
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Question 3

What antidepressant group is Venlafaxine

Answer 3

SNRI - Venlafaxine
◦ Side effects
◦ Drowsiness, dizziness, insomnia, headache
◦ Photosensitivity
◦ Ejaculation dysfunction

◦ Adverse effects
◦ Nephrotoxic
◦ Tachycardia, hypertension
◦ Orthostatic hypotension
◦ Suicidal ideation, seizures
◦ Stevens-Johnsons syndrome

Question 4

Contraindications of Venlafaxine

Answer 4

Interactions
◦ St. John’s wort
◦ Other CNS depressants/alcohol
◦ MAOI’s

◦ Contraindications
◦ Pregnancy, breastfeeding
◦ Anticoagulant therapy – increases risk for bleeding
◦ Suicidal ideation

Question 5

What antidepressant group is Amitryptyline

Answer 5

Tricyclic(TCA)

Side effects/adverse reactions
◦ CNS disturbances – dizzy, sedation
◦ Dry mouth and eyes
◦ Orthostatic hypotension
◦ Urinary retention, sexual dysfunction
◦ Weight gain

ADVERSE REACTION
◦ Suicidal ideation
◦ Cardiotoxicity (dysrhythmias)
◦ EPS, NMS

Question 6

Contraindications of Amitryptyline

Answer 6

◦ Interactions
◦ Alcohol and other CNS depressants potentiate CNS
depression
◦ Contraindications
◦ Cardiovascular disease
◦ Hypertension

Question 7

What Antidepressant Group is Phenelezine

Answer 7

MAOI - Monoamine Oxidase Inhibitors
(BIG BOY, ONLY USE WHEN OTHER ANTIDEPRESSANT DONT WORK)
MOAI - Phenelzine
•Side effects/adverse effects
> Agitation, restlessness, insomnia
> Anticholinergic effects
> Orthostatic hypotension

ADVERSE REACTION
• Hypertensive crisis from tyramine interaction
≥ Suicidal ideation