Tranexamic acid Flashcards
What is the trade name for tranexamic acid?
Cyklokapron
What is the generic name for Cyklokapron?
tranexamic acid
Classification - tranexamic acid
antifibrinolytic
How is tranexamic acid supplied?
100mg/ml solution, 500mg tablets
Actions (Pharmacodynamics) - tranexamic acid
❑ Inhibits the normal process of fibrin breakdown by preventing the formation of plasmin from plasminogen.
❑ Most useful for preventing recurring bleeding; it is less useful for stopping an on-going bleed.
Indications - tranexamic acid
❑ Bleeding within 3 hours of injury and presenting at any point with HR greater than 110 bpm or systolic BP less than 90 mmHg. Ex. TBI, Post-Partum hemorrhage, significant traumatic injury with internal bleeding.
Dosage - tranexamic acid
(>16 years old): 1 g IV/IO dilute in 250 mL D5W or 100ml Normal Saline bag and infuse over 10 minutes; followed by as soon as practical an infusion of 1 g over 8 hours
(<16 years old): 15mg/kg IV/IO to a max of 1g over 10 minutes. Follow bolus dose with 2mg/kg/hr IV/IO to a max of 1g over 8 hours.
Contraindications - tranexamic acid
❑ Hypersensitivity to Tranexamic Acid
❑ Active thromboembolic disease ( pulmonary embolus, DVT or stroke)
❑ Unable to initiate bolus within 3 hrs of injury onset
❑ GI Bleeds
Is the effectiveness of tranexamic acid time dependent? Explain.
TXA when given early decreases mortality. For every 15 minutes past the onset of the injury, TXA effectiveness decreases by 11%
What is the highest priority when giving tranexamic acid?
Administration of Tranexamic Acid should not delay transport; rapid transport to a trauma facility is still the highest priority.
What is the drip rate for tranexamic acid using a 10gtt?
To infuse 250 mL over 10 minutes the drip rate is 4 gtts/sec using a 10 gtt set
