Ticagrelor

Question 1

What is the trade name for ticagrelor

Answer 1

Brilinta

Question 2

What is the generic name for Brilinta?

Answer 2

ticagrelor

Question 3

Classification - Brilinta (ticagrelor)

Answer 3

P2Y platelet aggregation inhibitor; Antiplatelet

Question 4

How is Brilinta (ticagrelor) supplied?

Answer 4

90 mg tablet

Question 5

Actions (Pharmacodynamics) - Brilinta (ticagrelor)

Answer 5

Reduces platelet aggregation – reversibly inhibits platelet P2Y12 ADP receptor to prevent signal
transduction and platelet activation

Question 6

Indications - Brilinta (ticagrelor)

Answer 6

Reduction of thrombolytic cardiovascular events in conjunction with aspirin in patients with acute
coronary syndrome.

Question 7

Dosage - Brilinta (ticagrelor)

Answer 7

Adult – PO – 180 mg once (given with aspirin 325 mg) *AHS MCP Note: Dosage is as directed by VHR physician / protocol

Question 8

Contraindications - Brilinta (ticagrelor)

Answer 8

❑ Hypersensitivity
❑ History of intracranial hemorrhage
❑ active pathologic bleeding
❑ severe hepatic impairment

Question 9

Precautions - Brilinta (ticagrelor)

Answer 9

❑ Moderate hepatic impairment
❑ Renal impairment
❑ Risk factors for bleeding

Question 10

Why might Brilinta (ticagrelor) be used in place of ASA?

Answer 10

Initial treatment in patients with allergy to aspirin or major GI intolerance to ASA

Question 11

Should Brilinta (ticagrelor) be used in Pts scheduled for surgery?

Answer 11

Use should be discontinued 5 days prior to any surgery. Do not initiate in patients planning coronary artery bypass graft surgery.