Metoclopramide

Question 1

Generic name for Maxeran

Answer 1

Generic name for Maxeran is Metoclopramide

Question 2

Trade name for Metoclopramide

Answer 2

Trade name for Metoclopramide is Maxeran

Question 3

Classifications of Metoclopramide

Answer 3

Classifications of Metoclopramide are; antiemetic and GI stimulant

Question 4

MOA(pharmacodynamics) of Metoclopramide (2)

Answer 4

1. Antiemetic: inhibits dopamine receptors in the brains chemoreceptor trigger zone to inhibit or reduce N/V. It blocks the D2 receptors that interact with the CTZ, and serotonin-3 receptors from interacting with the vagus nerve. It acts on vagus-4 receptors increasing peristalsis
2. GI stimulant: Relieves esophageal reflux by increasing lower esophageal sphincter tone and reduces gastric stasis by stimulating upper GI tract, thus reducing gastric emptying time.

Question 5

Indications for Admin of Metoclopramide

Answer 5

1. Antiemetic (particularly with chemotherapy and postoperative)
2. Gastroesophageal reflux, facilitation of radiographic examination
3. Upper GI bleed, which will help with nausea and also help with pre intubation

Question 6

Dosage for Metoclopramide

Answer 6

10 Mg IM/SIVP over 2 mins (single dose); may give 10 mg in 50 ML NS over 15 minutes. Repeat every 8hours.

Question 7

Contraindications for Metoclopramide

Answer 7

1. Hypersensitivity
2. Pheochromocytoma
3. Epilepsy
4. Patients receiving drugs likely to cause extrapyramidal responses
5. MAOI in the last 14 days
6. Parkinson’s disease
7. Bowel obstruction

Question 8

Precautions When Administering Metoclopramide

Answer 8

• Hypertension
• depression
• NOT for pediatrics
• sedation and orthostatic hypotension