Acetaminophen

Question 1

What is the trade name for acetaminophen?

Answer 1

Tylenol

Question 2

What is the drug classification of acetaminophen?

Answer 2

Central analgesic; Non-narcotic analgesic, antipyretic

Question 3

How is acetaminophen supplied?

Answer 3

120 to 325 mg tablets

Question 4

Describe the MOA (pharmacodynamics) of acetaminophen.

Answer 4

• Inhibits prostaglandin synthesis through COX-2 inhibition in the CNS and to a lesser extent blocks pain impulses through peripheral action.
• Acts centrally on the hypothalamic heat regulating center, producing peripheral vasodilation (heat loss, skin erythema, diaphoresis)

Question 5

What are the indications for acetaminophen use?

Answer 5

Relief of mild to moderate pain, fever

Question 6

What is the ADULT dose for acetaminophen?

Answer 6

325 to 975 mg PO q4-6h ( daily max 4000mg)

1000mg IV q4-6h, max 4000mg daily

Question 7

What is the pediatric dose for acetaminophen?

Answer 7

10 to 15mg/kg/ PO/PR 4-6 hours to max of 60mg/kg/day

Question 8

List the contraindications to acetaminophen use.

Answer 8

• Hypersensitivity

- Severe hepatic impairment or severe active liver disease

Question 9

What is a precaution for acetaminophen use?

Answer 9

Use with caution in hepatic impairment; renal impairment, alcohol dependency

Question 10

Does acetaminophen cause histamine release?

Answer 10

Rarely

Question 11

What happens if acetaminophen is given with benzodiazepines?

Answer 11

There is a synergistic effect. They can be used in combination to maintain “sedation” for advanced airways and advanced procedures.

Question 12

Does acetaminophen have hypnotic activity?

Answer 12

Has little hypnotic activity

Question 13

What is the toxic dose of acetaminophen?

Answer 13

150mg/kg