Pantoprazole

Question 1

Generic Name for Pantoloc

Answer 1

Pantoprazole

Question 2

Trade Names for Pantoprazole

Answer 2

Pantoloc, Panto IV, Protonix, Protonix IV, Tecta

Question 3

Classification for Pantoprazole

Answer 3

Antiulcer agent, and proton pump inhibitor

Question 4

MOA (pharmacodynamics) of Pantoprazole

Answer 4

• Binds to the ATP pump in the basal gastric cell to prevent it from pumping protons (H+ ions) that will increase gastric acidity.
• Therapeutic effects: diminished accumulation of acid in the gastric lumen, with lessened acid reflux. Decreased acid secretion in hyper-secretory conditions

Question 5

Indications for Pantoprazole Admin

Answer 5

1. Erosive esophagitis associated with GERD

2. Upper and Lower GI Bleed (gastric and duodenal ulcers)

Question 6

Dosage for Pantoprazole

Answer 6

IV: 40-80mg SIVP

Infusion: 8 mg/hr for 8 hrs. Mix 200 mg in 500 mL normal saline giving a concentration of 4 mg/mL.

Question 7

Contraindications for Pantoprazole Admin

Answer 7

1. Hypersensitivity to rabeprazole/related drugs (benzimidazoles)
2. Pregnancy/nursing mother

Question 8

Precautions in Pantoprazole Admin

Answer 8

• Caution in patients with severe liver impairment

- May increase serum levels of phenytoin and diazepam

Question 9

Why are proton pump inhibitors (PPI’s), like Pantoprazole, indicated as first line therapy for upper/lower GI bleeds, erosive esophagitis, and GERD?

Answer 9

Because gastric acid can be a contributing factor to these conditions and PPI’s help reduce gastric acidity.