Octreotide

Question 1

Generic name for Sandostatin

Answer 1

The generic name for Sandostatin/Sandostatin LAR is Octreotide

Question 2

Trade name for Octreotide

Answer 2

the trade name for Octreotide is Sandostatin/Sandostatin LAR

Question 3

Classification for Octreotide

Answer 3

Antidiarrheal, Hormones (as per formulary)

Octapeptide is a type of peptide that mimics a naturally occurring hormone known as somatostatin.

Question 4

What is the MOA (pharmacodynamics) for octreotide

Answer 4

• Suppresses secretions of serotonin, gastroenterohepatic peptides, insulin, glucagon and growth hormone.
• Reduces secretion of fluids by intestine and pancreas.
• Causes vasoconstriction and reduces portal vessel pressures in the bleeding varices.

Question 5

Indications for Octreotide administration

Answer 5

1. Emergency management of bleeding esophageal varices in patient with liver cirrhosis and for protection against re-bleeding
2. Hypoglycemia secondary to oral hypoglycemic poisoning

Question 6

Dosages for Octreotide admin (2)

Answer 6

Oral hypoglycemic OD refractory to dextrose:
Adult: 100 mcg IV/IO/SC q 6 hours prn
Peds: 2 mcg/kg/IV/IO/SC Q 6 hours prn

Upper GI bleed:
50 mcg IV/IO SIVP, then start infusion at 50 mcg/hr. Mix 500 mcg into a 250 mL NS which results in a concentration of 2 mcg/mL

Question 7

Contraindications for Octreotide

Answer 7

Hypersensitivity

Question 8

Precautions for Octreotide

Answer 8

Consider lower doses for those with gallbladder disease or renal impairment.

Question 9

Notable Notes for Octreotide

Answer 9

• When giving octreotide, monitor glucose frequently.

- Octreotide may enhance the toxic effects of drugs that prolong the QT interval.