Methylprednisolone sodium succinate

Question 1

What is the trade name for methylprednisolone sodium succinate?

Answer 1

Solu- Medrol

Question 2

What is the drug classification for methylprednisolone sodium succinate (Solu-Medrol)?

Answer 2

glucocorticoid, anti-inflamatory

Question 3

How is Solu-Medrol supplied?

Answer 3

40 mg, 125 mg, 500 mg, 1,000 mg, 2,000 mg/vial

Question 4

Describe the MOA (Pharmacodynamics) of Solu-Medrol.

Answer 4

• Anti-inflammatory: Stimulates the synthesis of enzymes needed to decrease the inflammatory response.
• Also increases the amount of beta 2 receptors in the lung

Question 5

What are the indications for use of Solu-Medrol?

Answer 5

• Bronchospasm
• Anaphylactic shock
• Status asthmaticus

Question 6

What is the dose for Solu-Medrol?

Answer 6

Adult/Pediatric: 1-2 mg/kg IV to a max of 125mg q 6 hrs, given over 3 – 15 minutes

Question 7

List the contraindications to Solu-Medrol use

Answer 7

• Allergy to any formulation components
• Cushing’s syndrome
• Systemic fungal infections

Question 8

What is a precaution to consider when using Solu-Medrol?

Answer 8

Rapid IV injection of large doses have resulted in convulsions, anaphylaxis, dysrhythmias, and death

Question 9

How do you reconstitute Solu-Medrol

Answer 9

According to the manufactures directions using the supplied diluents or water for injection

Question 10

What is the recommended administration time frame for Solu-Medrol?

Answer 10

For doses greater than 0.5 g IV, give over at least 10 minutes to prevent arrhythmias and circulatory collapse. The recommended infusion rate is over at least 30 minutes.