Propofol Flashcards
What is the trade name for propofol?
Diprivan
What is the drug classification for propofol (Diprivan)?
anesthetic, sedative-hypnotic
How is propofol (Diprivan) supplied?
10 mg/mL in (20 mL, 50 mL and 100 mL vials)
Describe the MOA (pharmacodynamics) of propofol (Diprivan).
Anesthetic action: Has several MOAs, both through potentiation of GABA receptors activity, thereby slowing the channel-closing time, and also acting as a sodium channel blocker. (can be used to maintain anesthesia through careful titration of the infusion rate).
What are the indications for propofol (Diprivan)?
- Maintenance of general anesthesia in mechanically ventilated patients (best in hospital environment).
- Prolonged seizures refractory to benzos
What is the dose of propofol (Diprivan) for maintenance of general anesthesia/prolonged seizures?
Adult: 15 to 50 mcg/kg/min or 1 to 3mg/kg/hr IV/IO
Pediatric: 8 to 83mcg/kg/min or 0.5 to 5mg/kg/hr IV/IO
List the contraindications for propofol (Diprivan)
- Hypersensitivity to drug or emulsion (egg phospholipids, soybean oil etc)
- Pregnancy
List some precautions for the use of propofol (Diprivan).
- Hypovolemia and shock
- Hypotension can occur due to vasodilation.
- Increased ICP or impaired cerebral perfusion due to decreased systemic arterial pressure and subsequent cerebral perfusion pressure.
- Use cautiously in elderly or debilitated patients or those patients with impaired renal, hepatic function, severe cardiac or respiratory disease
Why is propofol administered in a lipid emulsion?
Propofol is highly lipid soluble (nearly insoluble in water) and so administered in a lipid emulsion. This
leads to rapid transfer across the blood brain barrier and rapid distribution to organs with high blood flow.
Does propofol have analgesic affects?
NO
Can propofol be used as an induction agent?
YES
