Enoxaparin sodium

Question 1

What is the trade name for enoxaparin sodium?

Answer 1

Lovenox

Question 2

What is the generic name for Levenox?

Answer 2

enoxaparin sodium

Question 3

Classification - Levenox (enoxaparin sodium)

Answer 3

low-molecular-weight heparin (LMWH)

Question 4

How is Levenox (enoxaparin sodium) supplied?

Answer 4

30mg/0.3ml ampoules; 30mg/0.3ml prefilled syringe

Question 5

Actions (Pharmacodynamics) - Levenox (enoxaparin sodium)

Answer 5

❑ Anticoagulation action: LMWH that accelerates formation of antithrombin III-thrombin complex and deactivates thrombin preventing conversion of fibrinogen to fibrin.

Question 6

Indications - Levenox (enoxaparin sodium)

Answer 6

Acute STEMI

Question 7

Dosage - Levenox (enoxaparin sodium)

Answer 7

<75 yr: Initial dose: 30mg IVP; Second dose 1mg/kg SQ (15 minutes following initial dose), Note: maximum dose of 100mg SQ (Maximum SQ dose does NOT include IV dose)

> 75 yr: Eliminate initial IV dose; Give 0.75 mg/kg SQ q 12 hours, Note: maximum dose 75mg SQ
AHS MCP – As directed by VHR physician / protocol

Question 8

Contraindications - Levenox (enoxaparin sodium)

Answer 8

❑ Hypersensitivity to heparin or pork products
❑ Active major bleeding or bleeding disorders
❑ Type II Heparin or LMWH induced thrombocytopenia
❑ Platelet count <100,000

Question 9

Precautions - Levenox (enoxaparin sodium)

Answer 9

❑ Renal and hepatic impairment
❑ Pregnancy or lactation
❑ Patients using anticoagualants
❑ Uncontrolled HTN
❑ Recent surgery 
❑ Renal insufficiency

Question 10

Notes - Levenox (enoxaparin sodium)

Answer 10

❑ Not recommended for pediatrics
❑ Also used for prevention of DVT and treatment of acute DVT (1.5mg/kg/day or 1mg/kg twice/day SQ)
❑ Used for ACS patients with unstable angina/NSTEMI, however, creatine levels must be obtained