Haloperidol

Question 1

Generic name for Haldol

Answer 1

Haloperidol

Question 2

Trade name for Haloperidol

Answer 2

Haldol

Question 3

Classification of Haloperidol

Answer 3

Antipsychotic

Question 4

MOA (Pharmacodynamics) for Haloperidol

Answer 4

Antipsychotic: Strong postsynaptic blockade of CNS dopamine receptors D1/D2, thereby inhibiting dopamine-mediated effects

Has many central and peripheral effects; has weak peripheral anticholinergic and antiemetic effects, produces both alpha and ganglionic blockade, and counteracts histamine and serotonin mediated activity.

Question 5

Indications for Haloperidol

Answer 5

• Acute psychotic crisis
• Psychosis/Excited Delirium
• Cannabis Hyperemesis

Question 6

Dosages for Haloperidol

Answer 6

Acute psychotic crisis: 2.5 – 5.0 mg IV/IM q 15 minutes prn; max total dose of 10 mg

Cannabis Hyperemesis: 1 - 2.5mg IV/IM
*Administer a single dose of 2.5 mg IM only for patients > 65 years of age or older.

Ped: 0.05mg/kg IM to a single max 5mg q 15minutes to a total max of 10mg

Question 7

Contraindications for Haloperidol

Answer 7

• Parkinson’s disease
• Hypersensitivity to drug or components
• Coma or CNS depression
• Narrow angle glaucoma
• History of seizures

Question 8

Precautions for Haloperidol

Answer 8

• Haldol lactate is for IV
• Haldol decanoate is an older form and only should be administered IM.
• Haldol IV is not approved for the treatment of patients with dementia-related psychosis
• Elderly and debilitated patients.
• Watch for extra pyramidal adverse effects.
• Coma and arrhythmias (like prolonged QT) are signs of overdose.
  -Patients receiving anticonvulsants, anticoagulants, CNS depressants, Rifampin, Methyldopa, lithium or
  other medication with anticholinergic effects

Question 9

Notable notes for Haloperidol

Answer 9

• Decanoate Haldol is for IM use only, and must NOT be given IV.
• May be mixed in the same syringe with midazolam for control of combative behavior