Ceftriaxone

Question 1

Generic name for Rocephin

Answer 1

Generic name for Rocephin is Ceftriaxone

Question 2

Trade name for Ceftriaxone

Answer 2

Trade name for Ceftriaxone is Rocephin

Question 3

Classification for Ceftriaxone

Answer 3

Classification for Ceftriaxone is; antibiotic

Question 4

MOA (pharmacodynamics) for Ceftriaxone

Answer 4

MOA(pharmacodynamics) for Ceftriaxone:

Binds to bacterial cell membranes and inhibits the cell wall synthesis; bactericidal

Question 5

Indications for Ceftriaxone Admin

Answer 5

Indications for Ceftriaxone Admin
-Treatment of susceptible infections due to gram-negative aerobic organisms, some gram positive organisms including
respiratory tract, GI/GU tract, skin and skin structure, bone and joint, intra-abdominal, PID, biliary tract/urinary
tract infections, bacterial septicemia, meningitis, atypical community acquired pneumonia

Question 6

Dosage for Ceftriaxone

Answer 6

Dosage for Ceftriaxone

Adult: 2 g IV/IO; use dilution of 2g in 100 ML NS; reconstitution- add 2.5 ML sterile water for injection to each 250 mg to provide concentration of 100 mg/ML; infuse over 30 mins

Pediatric: 100 mg/kg to a max of 2 g IV/IO, infuse over 30 mins

Question 7

Contraindications for Ceftriaxone Admin (2)

Answer 7

Contraindications for Ceftriaxone

1. Hypersensitivity to ceftriaxone
2. Do not administer with calcium containing IV solutions (ringers lactate)

Question 8

Precautions with Ceftriaxone Admin

Answer 8

Precautions with Ceftriaxone Admin

• Hepatic impairment
• Hx of GI disease
• Hx of Penicillin allergy

Question 9

Notable Notes with Ceftriaxone

Answer 9

Notable Notes, ceftriaxone

• Abdominal cramping, severe watery diarrhea and fever may result from altered bacterial balance
• Patients with history of Penicillin allergy are at an increased risk for developing a severe sensitivity reaction.
• Third Generation Broad Spectrum Antibiotic