Toxicology in Laboratory Techniques Flashcards
What is lead poisoning also called?
Plumbism
What are the clinical signs of lead poisoning?
GI tract
Nervous system
What are the lab findings of lead poisoning?
Basophilic stippling or increased nucleated RBCs
Not anemia
What are the examples of anticoagulant rodenticides?
Warfarin, Diphacinone, Pindone
How do the anticoagulant rodenticides do it?
They inhibit the metabolism of Vitamin K
What is required for the production of Factors II, VII, IX and X in the liver?
Vitamin K
What happens without vitamin K?
Coagulation time is prolonged and the animal bleeds out
What is suspected when both PT and PTT are prolonged?
Rodenticide Poisoning
Treatment is Vitamin K
What are the causes of Heinz Bodies Cats?
Paracetamol or acetaminophen and methylene blue
Prolonged/repeated Propofol usage
What are the causes of Heinz Bodies in Dogs?
Onions
What are the causes of Heinz Bodies in Horses?
Red Maple Leaves
What are the causes of Heinz Bodies in Ruminants?
Onions and Brassicas
Brussel sprouts, cabbage, cauliflower, broccoli
What is a major ingredient in antifreeze?
Ethylene Glycol
What does a histopathologic examination look like for an animal that has ethylene glycol toxicity?
Kidney will show renal tubular nephrosis
Calcium oxalate monohydrate crystals
