Topical Retinoids Flashcards
Tazarotene is a prodrug that is rapidly hydrolysed in tissues to the active metabolite termed tazarotenic acid
T
Excessive quantities of vitamin A adversely affect developing embryo
T
All trans retinoic acid is more stable chemically, less photolabile, and more Lipophilic than adapalene, allowing it to penetrate follicles quickly
False
Adapalene has these properties compared to all trans retinoic acid
Bexarotene binds RAR and RXR
F
Only RXR
Bexarotene interacts with DEET to increase DEET toxicity
T
Topical Bexarotene always results in central hypothyroidism like oral form
False
No studies to indicate this’s
Only trace amount of topical adapalene is abs and excreted through kidneys
F
HB route
Tazarotene does not bind RXR
T
Tazarotene has high affinity for RAR-a that is predominant receptor in epidermis
False
RAR-y
Bexarotene is highly protein bound
T
>99%
Bexarotene inhibits s phase of cell cycle
False
M, G1 and G2
Tazarotene is excreted via the hepatobiliary route and skin desquamation
False
Urine faces and skin
Rest are skin and hepatobiliary only
Excess Retinol is stored as retinyl esters in the lower layers of the epidermis
T
Excess Retinol is stored as retinyl esters in the lower layers of the epidermis
T
Comedolytic effects of topical retinoids are not maintained after ceasing
T
