Systemic Anticancer Agents Flashcards
Papulopustular rash most common derm toxicity with EGFRs
T
The presence and severity of papulopustular rash has a negative correlation with tumor response and patient survival
F
Surprisingly positive correlation
Xerosis from EGFR typically occurs 2-3 months after tx in 35% pt
T
Most frequently observed derm AE with sorafenib (an MKI) include rash/desquamation, hand foot skin reaction , alopecia , facial erythema, nail changes and pruritus
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MKI Imatinib associated with periorbital oedema in 70%
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The most common cutaneous AE to carboplatin is maculopapular rash
F
Alopecia
Patchy hyperpigmentation can occur in up to 70% patients treated with cisplatin
T
Antimicrotubule agents paclitaxel and decotaxel have been approved for AIDS related KS
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Histone deacetylase inhibitors are useful in CTCL
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Eg vorinostat
Romidepsin
Vorinostat may cause alopecia and rarely mucositis
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A noteworthy AE of gemcitabine (anti metabolite) is erythema resembling erysipelas
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Capecitabine is a prodrug of 5-FU
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Vemurafenib is an inhibitor of serine-threonine protein kinase BRAF
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AEs of vemurafenib
Rash Alopecia Photosensitivity reaction Pruritus Hyper keratosis Xerosis Ppe
EGFR inhibitors work by altering keratinocyte physiology , increasing premature differentiation , decreasing proliferation and inc apoptosis
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