Botox Flashcards

1
Q

Muscle weakness is seen at 2-4days whilst max paralysis at 7-10 days

A

T

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2
Q

Peripheral nerves sprout new smaller unmyelinated nerve endings within 1 month after Botox

A

T

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3
Q

Nerve repair is complete after 9 months - a functional connection is re established

A

F

3 months

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4
Q

Muscular hypertrophy may be seen with each Botox injection

A

F

Atrophy

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5
Q

Botox is extremely potent

A

T

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6
Q

Botox 1U is amount required to kill 50% of mice when injected peritoneallly

A

T

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7
Q

LD50 For Humans = 250-350 intraperitoneal Botox units

A

F

2500-3500

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8
Q

Neutralizing antibodies are those that form against the surface of Botox

A

F

Forms against the core

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9
Q

Botox a vials must be kept refrigerated

A

T

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10
Q

Evaluation of eyelid laxity with a snap test is important prior to periocular tx

A

T

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11
Q

Botox serotypes B, D, F and G catalyse cleavage of snare protein SNAP-25

A

F

Synaptobrevin AKA VAMP

ACE catalyse this protein

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