Botox Flashcards
Muscle weakness is seen at 2-4days whilst max paralysis at 7-10 days
T
Peripheral nerves sprout new smaller unmyelinated nerve endings within 1 month after Botox
T
Nerve repair is complete after 9 months - a functional connection is re established
F
3 months
Muscular hypertrophy may be seen with each Botox injection
F
Atrophy
Botox is extremely potent
T
Botox 1U is amount required to kill 50% of mice when injected peritoneallly
T
LD50 For Humans = 250-350 intraperitoneal Botox units
F
2500-3500
Neutralizing antibodies are those that form against the surface of Botox
F
Forms against the core
Botox a vials must be kept refrigerated
T
Evaluation of eyelid laxity with a snap test is important prior to periocular tx
T
Botox serotypes B, D, F and G catalyse cleavage of snare protein SNAP-25
F
Synaptobrevin AKA VAMP
ACE catalyse this protein