Miscellaneous Systemic Drugs Flashcards
T/F
Co administration of anticholinergic with SSRI’s may lead to increased anticholinergic adverse effects
False
Co admin with TCAs
T/F
The pharmacological effects of atenolol and digoxin may be increased by simultaneous use of anticholinergic agents
Eg glypyrrolate + propantheline
True
T/F
Anticholinergic agents may control symptoms of hyperhidrosis at low doses without appreciable side effects
True
Which synthetic derivatives of testosterone are used to treat hereditary angioedema?
Danazol
Stanozolol
Both have potent fibrinolytic activity
What are dermatological use of attenuated androgens ?
Lipodermatosclerosis
Livedoid vasculopathy
Cryofibrinogenaemia
T/F
Danozol and stanozolol are attenuated androgens alkylated at 17-a
True
Adverse effects of danozol and stanozolol
In female patients :Mild hirsutism Deepening of voice Alopecia Acne Menstrual irregularities Weight gain
Other : neuromuscular dysfunction eg. Muscle cramps , myalgias and elevations in serum creatine phosphokinase
T/F
Biotin is vitamin B7
True
Foods rich in biotin
Organ Meat Egg yolk Fish Nuts Milk
Signs of biotin deficiency
Thinning of hair
Poliosis
Seb derm like eruption (like zinc deficiency)
Clinical uses of biotin
Keratodermas 50mg daily
Dermatitic eruptions 5mg daily
What is clofazamine
The most active antimycobacterial riminophenazine dye known
T/F
Colchicine is an alkaloid which must be shielded from UV light
True
T/F
Colchicine Is metabolized by the liver ,the majority is eliminated through bile in faeces, and 10-20% of the dose is eliminated unchanged in the urine
True
What is colchicine MoA?
Binds to dimers of tubulin
Preventing their assembly into micro tubules
–> this results in mitotic arrest at metaphase and interference with cell motility and chemotaxis
Therefore both antimitotic and antiinflammatory.
What happens in colchicine overdose ?
Cholera like syndrome with dehydration , hypokalaemia,
Hyponat, metabolic acidosis , renal failure & shock
Use of gold in derm
DLE SLE pemphigoid EBA Psoriatic arthritis
T/F
Nicotinamide deficiency leads to pellagra
True
How Is nicotinamide anti inflammatory ?
Inhibits PARP-1,
A nuclear enzyme that enhances nuclear factor KB tx
Reduces lysosomal enzyme release & stabilises leukocytes by inh cAMP PDE
Inhibit mast cell degranulation
Potassium iodide MoA
Iodides in infected granulomas and necrotic tissue have been shown to inhibit granuloma formation
Suppress generation if inflammatory O2 intermediates
? Immunosuppressive effect mediated through release of heparin
Dermatological conditions with evidence of VitE deficiency
EBA
CLE
GA
Yellow nail syndrome
Cutaneous findings of zinc deficiency
Circumorificial and acral dermatitis + accompanying diarrhoea
Derm uses of Zinc
Inconsistent success in Acneiform conditions Alopecia Verrucae Acute cutaneous leishmaniasis Leg ulcers in persons with low zinc
Which are the two most frequently used anticholinergics on hyperhidrosis?
GLYCOPYRROLATE AND PROPANTHELINE
Potassium iodide may cause hypothyroidism
T
Clofazamine half life is 70 days
T
Colchicine binds directly to tubulin
F
To dimers of tubulin
Glycopyrrolate works by blocking effect of Ach on sweat glands
T
Glypyrrolate and propantheline side effects
Common- dry mouth blurred vision
Rare seizures hyperthermia, glaucoma
Stanozolol has been shown to increase collagen synthesis of cultured dermal fibroblasts
T
Beneficial effect in wound healing
Dan and Stan have sodium retaining effects
T
Thus can worsen hypertension. And CCF
Which conditions is biotin treatment for ?
Unna thost (uncombable hair) syndrome Brittle nails
Clofazimine inh mycobacterium tuberculosis
T
Clofazamine most common side effect is orange brown discoloration of the skin
T
2-4 weeks after commencement
Colchicine concentrates poorly in leukocytes
F
Extremely well
What can colchicine be used to treat ?
Behcets DH Sweets LABD IgA pemphigus EBA LCV Dermatomyositis Scleroderma Relapsing poky chondrites Pachydermoperiostosis
Colchicine can cause acute and chronic azoospermia
T
How does gold work as anti inflammatory ?
Inh phagocytic and chemotactic response or macrophages and PMN
Gold can cause keratitis with corneal ulceration
Deposits in cornea and lens– chrysiasis
T
Nicotinamide is assoc with flushing and pruritus
F
This is nicotinic acid (converted to nicotinamide in the body), a potent vasodilator
Nicotinamide has Few side effects
T
Rare headaches and GI
No flushing or pruritus
Mild iodism from KI simulates a head cold
T
Thalidomide half life
9 hours
Thalidomide is effective in erythema nodosum leprosum
T
Thalidomide may cause hypothyroidism
T
