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Pharmacology > Miscellaneous Systemic Drugs > Flashcards

Miscellaneous Systemic Drugs Flashcards

1
Q

T/F

Co administration of anticholinergic with SSRI’s may lead to increased anticholinergic adverse effects

A

False

Co admin with TCAs

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2
Q

T/F
The pharmacological effects of atenolol and digoxin may be increased by simultaneous use of anticholinergic agents
Eg glypyrrolate + propantheline

A

True

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3
Q

T/F

Anticholinergic agents may control symptoms of hyperhidrosis at low doses without appreciable side effects

A

True

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4
Q

Which synthetic derivatives of testosterone are used to treat hereditary angioedema?

A

Danazol
Stanozolol

Both have potent fibrinolytic activity

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5
Q

What are dermatological use of attenuated androgens ?

A

Lipodermatosclerosis
Livedoid vasculopathy
Cryofibrinogenaemia

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6
Q

T/F

Danozol and stanozolol are attenuated androgens alkylated at 17-a

A

True

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7
Q

Adverse effects of danozol and stanozolol

A 
In female patients :Mild hirsutism
Deepening of voice
Alopecia
Acne
Menstrual irregularities 
Weight gain

Other : neuromuscular dysfunction eg. Muscle cramps , myalgias and elevations in serum creatine phosphokinase

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8
Q

T/F

Biotin is vitamin B7

A

True

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9
Q

Foods rich in biotin

A 
Organ Meat
Egg yolk 
Fish
Nuts
Milk
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10
Q

Signs of biotin deficiency

A

Thinning of hair
Poliosis
Seb derm like eruption (like zinc deficiency)

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11
Q

Clinical uses of biotin

A

Keratodermas 50mg daily

Dermatitic eruptions 5mg daily

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12
Q

What is clofazamine

A

The most active antimycobacterial riminophenazine dye known

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13
Q

T/F

Colchicine is an alkaloid which must be shielded from UV light

A

True

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14
Q

T/F
Colchicine Is metabolized by the liver ,the majority is eliminated through bile in faeces, and 10-20% of the dose is eliminated unchanged in the urine

A

True

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15
Q

What is colchicine MoA?

A

Binds to dimers of tubulin
Preventing their assembly into micro tubules
–> this results in mitotic arrest at metaphase and interference with cell motility and chemotaxis

Therefore both antimitotic and antiinflammatory.

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16
Q

What happens in colchicine overdose ?

A

Cholera like syndrome with dehydration , hypokalaemia,

Hyponat, metabolic acidosis , renal failure & shock

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17
Q

Use of gold in derm

A 
DLE
SLE
pemphigoid
EBA
Psoriatic arthritis
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18
Q

T/F

Nicotinamide deficiency leads to pellagra

A

True

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19
Q

How Is nicotinamide anti inflammatory ?

A

Inhibits PARP-1,
A nuclear enzyme that enhances nuclear factor KB tx

Reduces lysosomal enzyme release & stabilises leukocytes by inh cAMP PDE

Inhibit mast cell degranulation

20
Q

Potassium iodide MoA

A

Iodides in infected granulomas and necrotic tissue have been shown to inhibit granuloma formation

Suppress generation if inflammatory O2 intermediates

? Immunosuppressive effect mediated through release of heparin

21
Q

Dermatological conditions with evidence of VitE deficiency

A

EBA
CLE
GA
Yellow nail syndrome

22
Q

Cutaneous findings of zinc deficiency

A

Circumorificial and acral dermatitis + accompanying diarrhoea

23
Q

Derm uses of Zinc

A 
Inconsistent success in
Acneiform conditions
Alopecia
Verrucae 
Acute cutaneous leishmaniasis
Leg ulcers in persons with low zinc
24
Q

Which are the two most frequently used anticholinergics on hyperhidrosis?

A

GLYCOPYRROLATE AND PROPANTHELINE

25
Q

Potassium iodide may cause hypothyroidism

A

T

26
Q

Clofazamine half life is 70 days

A

T

27
Q

Colchicine binds directly to tubulin

A

F

To dimers of tubulin

28
Q

Glycopyrrolate works by blocking effect of Ach on sweat glands

A

T

29
Q

Glypyrrolate and propantheline side effects

A

Common- dry mouth blurred vision

Rare seizures hyperthermia, glaucoma

30
Q

Stanozolol has been shown to increase collagen synthesis of cultured dermal fibroblasts

A

T

Beneficial effect in wound healing

31
Q

Dan and Stan have sodium retaining effects

A

T

Thus can worsen hypertension. And CCF

32
Q

Which conditions is biotin treatment for ?

A 
Unna thost (uncombable hair) syndrome
Brittle nails
33
Q

Clofazimine inh mycobacterium tuberculosis

A

T

34
Q

Clofazamine most common side effect is orange brown discoloration of the skin

A

T

2-4 weeks after commencement

35
Q

Colchicine concentrates poorly in leukocytes

A

F

Extremely well

36
Q

What can colchicine be used to treat ?

A 
Behcets
DH
Sweets
LABD
IgA pemphigus 
EBA
LCV
Dermatomyositis
Scleroderma
Relapsing poky chondrites
Pachydermoperiostosis
37
Q

Colchicine can cause acute and chronic azoospermia

A

T

38
Q

How does gold work as anti inflammatory ?

A

Inh phagocytic and chemotactic response or macrophages and PMN

39
Q

Gold can cause keratitis with corneal ulceration

Deposits in cornea and lens– chrysiasis

A

T

40
Q

Nicotinamide is assoc with flushing and pruritus

A

F

This is nicotinic acid (converted to nicotinamide in the body), a potent vasodilator

41
Q

Nicotinamide has Few side effects

A

T
Rare headaches and GI
No flushing or pruritus

42
Q

Mild iodism from KI simulates a head cold

A

T

43
Q

Thalidomide half life

A

9 hours

44
Q

Thalidomide is effective in erythema nodosum leprosum

A

T

45
Q

Thalidomide may cause hypothyroidism

A

T

Pharmacology (63 decks)

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