Topical And I/L Chemo Agents

Question 1

Vincristine is a vinca alkaloid that disrupts micro tubular function

Answer 1

True

Question 2

Nitrogen mustards highly react with DNA resulting in donation of alkyl group to DNA - disrupting normal cell function

Answer 2

T

Question 3

Nitrogen mustards alkylate DNA

Answer 3

T

Question 4

Most common adverse effect of topical nitrogen mustard is irritant or ACD

Answer 4

T

Question 5

Carmustine is an alkylating agent

Leads to interstrand or intrastrand cross linking of DNA

Answer 5

T

Question 6

Vinblastine is independent of cell cycle

Answer 6

False

Is cell cycle specific

Question 7

Vincristine is used in haematologic malignancies and nephroblastomas

Answer 7

T

Question 8

Bleomycin was discovered as fermentation product of strep verticillus

Answer 8

T

Question 9

Bleomycin leads to single and double stranded breaks in DNA

Answer 9

T

Question 10

5-FU metabolites ablock the function of thymidylate reductase

Answer 10

F

Thymidylate synthetase

Question 11

Allergic contact dermatitis is more common with ointment than Aqueous cream formulation of mechlorethamine

Answer 11

T

Question 12

Carmustine is an alkylating agent

Answer 12

T

Question 13

Severe pain and ulceration is common with vincristine

Answer 13

F

Rare

Question 14

Bleomycin acts during M and G2 phases of cell cycle

Answer 14

T