31. Psychotropic Agents Flashcards
One unique effect of alprazolam is its antidepressant effect
T
Buspirone can be used on a PRN basis
F
Takes 2-4 weeks onset of action
Doxepin has strong antipruritic effects as it is a very powerful H1 antihistamine
T
Alprazolam is indicated for acute and self limited stress
T
There is a 50 fold difference in trough blood levels among ind on same dose doxepin
T
Doxepin is metabolize by cyp3a4
F
2D6
Doxepin is associated with hypertension and weight loss
F
Hypotension
Weight gain
Cardiac conduction disturbance
Which drugs require pre treatment ECG
Doxepin
Pimozide
What are the discontinuation symptoms of stopping TCAs?
Uncomfortably vivid dreams Transient dizziness Nausea Headache Diaphoresis Insomnia Malaise
Patients showing no improvement after 2 weeks should switch to another Ssri
F
6 weeks
SSRIs have 5% incidence sexual difficulties
F
40%
Switching to another class of antidepressants is appropriate when sexual adverse effects occur . Which class had less sexual dysfunction ?
Bupropion
Discontinuation symptoms can occur with SSRIs and venlafaxine
T
Taper off slowly
Rather than abruptly
Bupropion is not associated with seizure induction
F
Long term Pimozide use is best avoided to minimisr risk of tardive dyskinesia
T
Most common side effects of risperidone are anxiety dizziness and rhinitis
T
There is a 50 fold difference in trough blood levels among ind on same dose doxepin
T
Doxepin is metabolize by cyp3a4
F
2D6
Doxepin is associated with hypertension and weight loss
F
Hypotension
Weight gain
Cardiac conduction disturbance
Which drugs require pre treatment ECG
Doxepin
Pimozide
What are the discontinuation symptoms of stopping TCAs?
Uncomfortably vivid dreams Transient dizziness Nausea Headache Diaphoresis Insomnia Malaise
MINDHUrT
Patients showing no improvement after 2 weeks should switch to another Ssri
F
6 weeks
SSRIs have 5% incidence sexual difficulties
F
40%
Switching to another class of antidepressants is appropriate when sexual adverse effects occur . Which class had less sexual dysfunction ?
Bupropion
Discontinuation symptoms can occur with SSRIs and venlafaxine
T
Taper off slowly
Rather than abruptly
Bupropion is not associated with seizure induction
F
Long term Pimozide use is best avoided to minimisr risk of tardive dyskinesia
T
Most common side effects of risperidone are anxiety dizziness and rhinitis
T
Most common ssri side effect is weight gain
F
Nausea and diarrhoea
Pimozide is a potent centrally acting dopamine receptor agonist
F
Dopamine rec antagonist
Venlafaxine has no sexual dysfunction
F
Less than SSRIs though
Most common se of venlafaxine
Nervousness anxiety insomnia
Bupropion is a weak inhibitor of dopamine re uptake
T
Doxepin has a much higher affinity for histamine receptors than traditional antihistamines
T
Night time dose of doxepin provides therapeutic benefit for 24h
T
