Topical Antiparasitic Agents

Question 1

How is permethrin metabolized and excreted ?

Answer 1

Metabolized Through ester cleavages and virtually all of absorbed permethrin is excreted via urine within one week

Question 2

Permethrin MoA

Answer 2

Reported to act on the cell membrane of Arthropods by disabling the sodium transport mechanism, which is responsible for maintenance of polarization of arthropod neuro membranes

Scabies mite is paralyzed

Question 3

Permethrin 3% cream is the treatment of choice for scabies

Answer 3

False 5%

Question 4

Permethrin is a synthetic pyrethroid , which are like natural pyrethrins (derived from Compositae; a relative of crysanthemum)

Answer 4

T

Question 5

Malathion inhibits glutamate gates chloride ion channels leading to neuromuscular paralysis in Arthropods

Answer 5

False
Inhibits acetylcholine
Ivermectin inhibits chloride ion channels