PUVA Flashcards
Food slows absorption of psoralens
T
Food slows absorption of psoralens
T
Psoralens are slowly excreted
F
Psoralens are metabolized in liver
T
Lactation is a relative CI
False
Absolute
Human contact with plants containing psoralens and subsequent exposure to sunlight results in phytophotodermatitis
T
There is an extremely low incidence of allergic sensitization to psoralens as they appear significantly in fruits and vegetables
T
Pregnancy is an absolute CI
F
Relative
When 95% or more of the original area of psoriasis had cleared , patient is changed to a maintenance schedule on PUVA
T
Bullous pemphigoid and pemphigoid can be treated with PUVA
F
Absolute CI
Need to dose reduce doxy by 25% when using PUVA
T
8-MOP is given at a dose of 4mg/kg
F
0.4mg/kg
Thiazide diuretics may augment photo toxicity of PUVA
F
Doxycycline and fluoroquinolones
Food intake can be used to alleviate problem of nausea when 8-MOP given orally
T
MoA of psoralens
Suppress DNA synthesis Photo immunologic reactions (Selective immunosuppression) Selective cytotoxicity Stimulation of melanocytes
Dose reduce doxy and fluoroquinolones with PUVA
T
Nausea is an uncommon side effect of 8-MOP
F
Common
Photoaging of skin can occur with long term PUVA
T
An ophthalmic exam should be obtained close to baseline with PUVA
T
Annual ocular exam recommended on PUVA
T
PUVA can be used to treat PMLE
NBUVB has PMLE is an AE
T
Psoralens are water
Soluble
Insoluble
In tx of vitiligo, face is most responsive to PUVA , then trunk then lower limbs
T
Eye protection needs to be worn from tint if psoralen exposure until sunset that day
T
